Comparative activity of ertapenem against extended-spectrum beta lactamase-producing or plasmid-mediated AmpC beta lactamase-producing Klebsiella pneumoniae

被引：3
作者：
Ramon Hernandez, Jose [1 ]
del Carmen Conejo, Maria [1 ]
Pascual, Alvaro [1 ,2 ]
机构：
[1] Univ Seville, Fac Med, Dept Microbiol, Seville, Spain
[2] Hosp Univ Virgen Macarena, Dept Microbiol, Seville, Spain
来源：
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2010年 / 28卷 / 01期
关键词：
Ertapenem; Extended-spectrum beta-lactamase; Plasmid AmpC; Porin; Inoculum effect; IN-VIVO DEVELOPMENT; ESCHERICHIA-COLI; CLINICAL ISOLATE; RESISTANCE; COMBINATION; GENES;
D O I：
10.1016/j.eimc.2009.03.003
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Introduction: The effect of porin loss and inoculum size on the comparative activity of ertapenem against either extended-spectrum beta lactamase-producing (ESBL) or plasmid-mediated AmpC beta lactamase-producing (pACBL) Klebsiella pneumoniae strains was evaluated. Methods: Microdilution using 2 different bacterial inocula. Results: Imipenem, amikacin, ertapenem, and cefepime were the most active agents under standard conditions. Ertapenem was more highly affected by porin loss than imipenem. Conclusions: Ertapenem showed high activity against K. pneumoniae strains expressing ESBL, pACBL OF both. Strains deficient in porins showed decreased susceptibility to beta lactams. The inoculum effect had a greater impact on imipenem than on ertapenem. (C) 2008 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：27 / 30
页数：4
相关论文
共 17 条
[1]   Comparative in vitro activity and the inoculum effect of ertapenem against Enterobacteriaceae resistant to extended-spectrum cephalosporins [J].
Betriu, Carmen ;
Salso, Santiago ;
Sanchez, Aida ;
Culebras, Esther ;
Gomez, Maria ;
Rodriguez-Avial, Iciar ;
Picazo, Juan J. .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2006, 28 (01) :1-5
[2]   Molecular characterization of FOX-4, a new ampC-type plasmid-mediated β-lactamase from an Escherichia coli strain isolated in Spain [J].
Bou, G ;
Oliver, A ;
Ojeda, M ;
Monzón, C ;
Martínez-Beltrán, J .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2549-2553
[3]   Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the loss of an outer membrane protein [J].
Bradford, PA ;
Urban, C ;
Mariano, N ;
Projan, SJ ;
Rahal, JJ ;
Bush, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :563-569
[4]   Genes encoding TEM-4, SHV-2, and CTX-M-10 extended-spectrum β-lactamases are carried by multiple Klebsiella pneumoniae clones in a single hospital (Madrid, 1989 to 2000) [J].
Coque, TM ;
Oliver, A ;
Pérez-Díaz, C ;
Baquero, F ;
Cantón, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (02) :500-510
[5]  
DIAZ MA, 2008, ENFERM INFE IN PRESS
[6]   In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase [J].
Elliott, E ;
Brink, AJ ;
van Greune, J ;
Els, Z ;
Woodford, N ;
Turton, J ;
Warner, M ;
Livermore, DM .
CLINICAL INFECTIOUS DISEASES, 2006, 42 (11) :E95-E98
[7]   Do CTX-M β-lactamases hydrolyse ertapenem? [J].
Girlich, Delphine ;
Poirel, Laurent ;
Nordmann, Patrice .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) :1155-1156
[8]   CTX-M Expression and Selection of Ertapenem Resistance in Klebsiella pneumoniae and Escherichia coli [J].
Girlich, Delphine ;
Poirel, Laurent ;
Nordmann, Patrice .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (02) :832-834
[9]   Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum β-lactamases in Spain [J].
Hernández, JR ;
Martínez-Martínez, L ;
Cantón, R ;
Coque, TM ;
Pascual, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (05) :2122-2125
[10]   Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in spanish hospitals (GEIH-BLEE Project 2002) [J].
Hernández, JR ;
Pascual, A ;
Cantón, R ;
Martinez-Martínez, L .
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2003, 21 (02) :77-82
12