Cytochrome P450 systems - biological variations of electron transport chains

被引:612
作者
Hannemann, Frank [1 ]
Bichet, Andreas [1 ]
Ewen, Kerstin M. [1 ]
Bernhardt, Rita [1 ]
机构
[1] Univ Saarland, D-66041 Saarbrucken, Germany
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2007年 / 1770卷 / 03期
关键词
cytochrome P450; electron transfer; heme-thiolate protein; monooxygenase; redox partner; P450; system; ARCHAEON SULFOLOBUS-SOLFATARICUS; SELF-SUFFICIENT CYTOCHROME-P450; MITOCHONDRIAL P450 SYSTEMS; FUNGUS FUSARIUM-OXYSPORUM; BETA-CAROTENE HYDROXYLASE; SITE-DIRECTED MUTAGENESIS; ACID HYDROPEROXIDE LYASE; COLI EXPRESSION SYSTEM; DIVINYL ETHER SYNTHASE; ALLENE OXIDE SYNTHASE;
D O I
10.1016/j.bbagen.2006.07.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cytochromes P450 (P450) are hemoproteins encoded by a superfamily of genes nearly ubiquitously distributed in different organisms from all biological kingdoms. The reactions carried out by P450s are extremely diverse and contribute to the biotransformation of drugs, the bioconversion of xenobiotics, the bioactivation of chemical carcinogens, the biosynthesis of physiologically important compounds such as steroids, fatty acids, eicosanoids, fat-soluble vitamins and bile acids, the conversion of alkanes, terpenes and aromatic compounds as well as the degradation of herbicides and insecticides. Cytochromes P450 belong to the group of external monooxygenases and thus receive the necessary electrons for oxygen cleavage and substrate hydroxylation from different redox partners. The classical as well as the recently discovered P450 redox systems are compiled in this paper and classified according to their composition. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:330 / 344
页数:15
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