Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology

被引：148

作者：

Das, Debapratim ^{[1
]}

Assaf, Khaleel, I ^{[2
,3
]}

Nau, Werner M. ^{[2
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati, India

[2] Jacobs Univ Bremen, Dept Life Sci & Chem, Bremen, Germany

[3] Al Balqa Appl Univ, Fac Sci, Dept Chem, Al Salt, Jordan

来源：

FRONTIERS IN CHEMISTRY | 2019年 / 7卷

关键词：

molecular containers; host-guest complexes; drug delivery; supramolecular chemistry; drug release; molecular recognition; chemosensing; HOST-GUEST COMPLEXES; NEUROMUSCULAR BLOCKING-AGENTS; SUPRAMOLECULAR PK(A) SHIFTS; HIGH-ENERGY WATER; MOLECULAR RECOGNITION; DRUG-DELIVERY; AMINO-ACIDS; CONTROLLED-RELEASE; IN-SITU; FLUORESCENCE ENHANCEMENT;

D O I：

10.3389/fchem.2019.00619

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and very low cytotoxicity. In this review, we summarize the host-guest complexation of biologically important molecules with CBn, and highlight their implementation in medicinal chemistry and chemical biology.

引用

页数：23

共 193 条

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