Efficacy of dietary nitrate-rich beetroot juice supplementation in patients with chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis

被引：15

作者：

Alshafie, Somia ^{[1
]}

El-Helw, Ghidaa Osama ^{[2
]}

Fayoud, Aya M. ^{[3
]}

Elrashedy, Asmaa Ahmed ^{[4
]}

Gbreel, Mohamed Ibrahim ^{[5
]}

Alfayoumi, Saba Saleh ^{[6
]}

Mohamed, Islam Mayhoub ^{[7
]}

Abdelwadoud, Gehad Taha ^{[8
]}

Isa, Alaa Saad ^{[9
]}

Ragab, Khaled Mohamed ^{[10
]}

Nourelden, Anas Zakarya ^{[11
,12
]}

机构：

[1] Suez Canal Univ, Fac Med, Ismailia, Egypt

[2] Beni Suef Univ, Fac Med, Bani Suwayf, Egypt

[3] Kafr El Shaikh Univ, Fac Pharm, Kafr Al Sheikh, Egypt

[4] Kafr El Shaikh Univ, Fac Med, Kafr Al Sheikh, Egypt

[5] 6 October Univ, Fac Med, Cairo, Egypt

[6] Univ Jordan, Fac Med, Amman, Jordan

[7] Beni Suef Univ, Fac Pharm, Bani Suwayf, Egypt

[8] Fayoum Univ, Fac Med, Faiyum, Egypt

[9] Al Azhar Univ, Fac Med, Dumyat, Egypt

[10] Minia Univ, Fac Med, Al Minya, Egypt

[11] Al Azhar Univ, Fac Med, Cairo, Egypt

[12] Int Med Students Res Assoc IMedRA, Cairo, Egypt

来源：

CLINICAL NUTRITION ESPEN | 2021年 / 42卷

关键词：

Chronic obstructive pulmonary disease; COPD; Nitrate; Beetroot juice; Exercise performance; Meta-analysis; EXERCISE PERFORMANCE; BLOOD-PRESSURE; EFFICIENCY; NITRITE; MUSCLE; COST;

D O I：

10.1016/j.clnesp.2021.01.035

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease causing airflow obstruction from the lungs reducing exercise tolerance. It is one of the leading causes of respiratory dysfunction worldwide. Nitric Oxide (NO) may have a significant role in this inflammatory reaction to improve exercise capacity. Aim: To evaluate the effect of dietary nitrate ingestion for COPD patients. Methods: We searched Scopus, PubMed, Cochrane, and Web of Science databases till August 2020 and updated the search in December 2020 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included articles and pooled them as mean difference (MD) with a 95% confidence interval (CI), using Review Manager software (ver. 5.4). Results: A pooled analysis from eight included trials showed no significant difference between dietary nitrate-rich beetroot juice and placebo in systolic blood pressure, diastolic blood pressure, heart rate, 6-min walk test, cycling ergometry endurance time, and maximum rate of oxygen consumption (VO2). On the other hand, nitrate-rich beetroot juice significantly increased the Borg Rating of Perceived Exertion (RPE) scale more than the placebo (MD = -0.77; 95% CI [0.18, 1.37], P = 0.01). Conclusion: There is no significant effect of nitrate-rich beetroot juice on cardiovascular events as systolic, diastolic blood pressure, and heart rate, or exercise performance as 6-min walk test, and cycling ergometry endurance time, or maximum rate of oxygen consumption (VO2). On the other hand, nitrate-rich beetroot juice improves the Borg Rating of Perceived Exertion (RPE) scale reflecting an increased exercise and physical activity level. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

引用

页码：32 / 40

页数：9

共 34 条

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