Tissue engineering of bone tissue. Principles and clinical applications

被引：0

作者：

Schmidt-Rohlfing, B. ^{[1
]}

Tzioupis, C. ^{[2
]}

Menzel, C. L. ^{[2
,3
]}

Pape, H. C. ^{[1
,2
]}

机构：

[1] Univ Klinikum RWTH Aachen, Klin Orthopad & Unfallchirurg, D-52074 Aachen, Germany

[2] Univ Pittsburgh, McGowan Inst Tissue Engn, Pittsburgh, PA 15260 USA

[3] Charite Univ Med Berlin, Berlin, Germany

来源：

UNFALLCHIRURG | 2009年 / 112卷 / 09期

关键词：

Tissue engineering; Bone tissue; Fracture healing; Non-union; Scaffold; Growth factor; STEM-CELLS; OSTEOBLASTS; REPAIR; MATRIX; HYDROXYAPATITE; SCAFFOLDS; DEFECTS; CULTURE; DESIGN;

D O I：

10.1007/s00113-009-1695-x

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Complex fractures are still a major clinical challenge. The treatment options of large bony defects either with autografts or allografts are limited in terms of material availability and tissue in-growth. Tissue engineering might offer a solution to this problem. In an interdisciplinary approach artificial bony tissue can be generated which mimics normal bone in terms of function and morphology. So far tissue engineering of bone is mainly confined to laboratory investigations whereas clinical applications are still in the beginning. This manuscript presents the most important scaffolds as well as growth factors and cell systems. Furthermore, it focuses on clinical studies for the treatment of large bony defects using tissue engineered cell-matrix constructs.

引用

页码：785 / 794

页数：10