Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)

被引：17

作者：

Ali, Abdelselam

Bliese, Marianne

Rasmussen, Jo-Anne M.

Sargent, Roger M.

Saubern, Simon

Sawutz, David G.

Wilkie, John S.

Winkler, David A.

Winzenberg, Kevin N.

Woodgate, Ruth C. J.

机构：

[1] CSIRO, Clayton, Vic 3168, Australia

[2] Schering Plough Pty Ltd, Baulkham, NSW 2153, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 04期

关键词：

(Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile; parasiticide; Haemonchus contortus; Ctenocephalides felis (cat flea);

D O I：

10.1016/j.bmcl.2006.11.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalidesfells. Some compounds had significant in vitro activity against these parasites. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：993 / 997

页数：5

共 8 条

[1] H-1-NMR, ULTRAVIOLET AND INFRARED-SPECTRA OF SOME (Z)-ALPHA-(PHENYL)-BETA-(2-FURYL), (2-PYRROLYL) AND (N-METHYL-2-PYRROLYL)ACRYLONITRILES [J].