Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs

被引：253

作者：

Omar, Kouatli ^{[1
]}

Geronikaki, Athina ^{[1
]}

Zoumpoulakis, Panagiotis ^{[2
]}

Camoutsis, Charalabos ^{[3
]}

Sokovic, Marina ^{[4
]}

Ciric, Ana ^{[4
]}

Glamoclija, Jasmina ^{[4
]}

机构：

[1] Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem Aristotle, GR-54006 Thessaloniki, Greece

[2] Natl Hellen Res Fdn, Lab Mol Anal, Inst Organ & Pharmaceut Chem, Athens 11635, Greece

[3] Univ Patras, Sch Hlth Sci, Dept Pharm, Lab Pharmaceut Chem, Patras, Greece

[4] Inst Biol Res, Mycol Lab, Dept Plant Physiol, Belgrade 11000, Serbia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 01期

关键词：

4-Thiazolidinone; Antibacterial; Antifungal; Z/E isomerism; ANTIMICROBIAL ACTIVITY; ADAMANTANE; THIAZOLIDINONE; DESIGN; VIRUS;

D O I：

10.1016/j.bmc.2009.10.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole, thiazolidinone and adamantane was synthesized by the multi-step reaction protocol, already reported in the literature. NMR and Molecular Modeling techniques were employed for structure elucidation and Z/E potential isomerism configuration of the analogues. Evaluation of antibacterial and antifungal activity showed that almost all compounds exhibited better results than reference drugs thus they could be promising candidates for novel drugs. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：426 / 432

页数：7

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