Pathophysiology of focal segmental glomerulosclerosis

被引：59

作者：

Reidy, Kimberly

Kaskel, Frederick J.

机构：

[1] Childrens Hosp Montefiore, Div Pediat Nephrol, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Childrens Hosp Montefiore, Bronx, NY 10467 USA

来源：

PEDIATRIC NEPHROLOGY | 2007年 / 22卷 / 03期

关键词：

focal segmental glomerulosclerosis (FSGS); nephrotic syndrome; pathophysiology; podocyte; injury; animal models; nephrin; podocin; transforming growth factor (TGF beta); tubulointerstitial;

D O I：

10.1007/s00467-006-0357-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the experimental and clinical data on the pathophysiology of FSGS.

引用

页码：350 / 354

页数：5

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