Optical tweezer for probing erythrocyte membrane deformability

被引：7

作者：

Khan, Manas ^{[1
]}

Soni, Harsh ^{[1
]}

Sood, A. K. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India

来源：

APPLIED PHYSICS LETTERS | 2009年 / 95卷 / 23期

关键词：

RED-BLOOD-CELL; VISCOSITY; DRIVEN; VISCOELASTICITY; DEFORMATION; NANOROTORS; ELASTICITY; SUSPENSION; MALARIA; ROTOR;

D O I：

10.1063/1.3272269

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We report that the average rotation speed of optically trapped crenated erythrocytes is direct signature of their membrane deformability. When placed in hypertonic buffer, discocytic erythrocytes are subjected to crenation. The deformation of cells brings in chirality and asymmetry in shape that makes them rotate under the scattering force of a linearly polarized optical trap. A change in the deformability of the erythrocytes, due to any internal or environmental factor, affects the rotation speed of the trapped crenated cells. Here we show how the increment in erythrocyte membrane rigidity with adsorption of Ca++ ions can be exhibited through this approach. (C) 2009 American Institute of Physics. [doi: 10.1063/1.3272269]

引用

页数：3

共 25 条

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