Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model

被引：16

作者：

Ruhlen, Rachel L. ^{[1
]}

Willbrand, Dana M. ^{[1
]}

Besch-Williford, Cynthia L. ^{[3
]}

Ma, Lixin ^{[2
,4
,5
]}

Shull, James D. ^{[6
]}

Sauter, Edward R. ^{[1
]}

机构：

[1] Univ Missouri, Dept Surg, Columbia, MO 65212 USA

[2] Univ Missouri, Biomol Imaging Ctr, Harry S Truman Mem Vet Hosp, Columbia, MO 65212 USA

[3] Dept Vet Biomed Sci, Columbia, SC USA

[4] Dept Radiol, Columbia, SC USA

[5] Int Inst Nano & Mol Med, Columbia, SC USA

[6] Univ Nebraska Med Ctr, Dept Genet Cell Biol & Anat, Columbia, SC USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2009年 / 117卷 / 03期

关键词：

ACI rat; Breast cancer etiology; Breast cancer prevention; Tamoxifen; Estrogen receptor; Rat model; ESTROGEN-INDUCED MAMMARY; HUMAN-BREAST-CANCER; HORMONE-REPLACEMENT THERAPY; DIETARY ENERGY RESTRICTION; FEMALE ACI RATS; COPENHAGEN RAT; INDUCED TUMORIGENESIS; RECIPROCAL CROSSES; TUMOR-DEVELOPMENT; GENETIC BASES;

D O I：

10.1007/s10549-008-0169-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5-7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonance imaging, by 89%. Tumors expressed estrogen receptors (ER), progesterone receptor (PR), and Erbb2. ER alpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers.

引用

页码：517 / 524

页数：8

共 37 条

[1] Nonrandom pattern of chromosome aberrations in 17β-estradiol-induced rat mammary tumors:: Indications of distinct pathways for tumor development [J].

Adamovic, Tatjana ;

Roshani, Leyla ;

Chen, Lei ;

Schaffer, Beverly S. ;

Helou, Khalil ;

Levan, Goran ;

Olsson, Bjorn ;

Shull, James D. .

GENES CHROMOSOMES & CANCER, 2007, 46 (05) :459-469

[2] Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats [J].

Aiyer, Harini S. ;

Srinivasan, Cidambi ;

Gupta, Ramesh C. .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2008, 60 (02) :227-234

[3]

Beral Valerie, 2003, Lancet, V362, P419

[4] Both ovarian hormones estrogen and progesterone are necessary for hormonal mammary carcinogenesis in ovariectomized ACI rats [J].

Blank, Edward W. ;

Wong, Po-Yin ;

Lakshmanaswamy, Rajkumar ;

Guzman, Raphael ;

Nandi, Satyabrata .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3527-3532

[5]

Collaborative Group on Hormonal Factors in Breast Cancer, 1997, LANCET, V350, P1047

[6] Prevention of hormone-related cancers: Breast cancer [J].

Dunn, BK ;

Wickerham, L ;

Ford, LG .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (02) :357-367

[7] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

[8] Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 study [J].

Fisher, B ;

Costantino, JP ;

Wickerham, DL ;

Redmond, CK ;

Kavanah, M ;

Cronin, WM ;

Vogel, V ;

Robidoux, A ;

Dimitrov, N ;

Atkins, J ;

Daly, M ;

Wieand, S ;

Tan-Chiu, E ;

Ford, L ;

Wolmark, N .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (18) :1371-1388

[9]

FULTON AM, 2000, P AM ASSOC CANC RES, V41, pA3660

[10] Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat:: Mapping of Emca1 and Emca2 to chromosomes 5 and 18 [J].

Gould, KA ;

Tochacek, M ;

Schaffer, BS ;

Reindl, TM ;

Murrin, CR ;

Lachel, CM ;

VanderWoude, EA ;

Pennington, KL ;

Flood, LA ;

Bynote, KK ;

Meza, JL ;

Newton, MA ;

Shull, JD .

GENETICS, 2004, 168 (04) :2113-2125

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