Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review

被引：24
作者：
Yarmohammadi, Fatemeh [1 ,2 ]
Hayes, A. Wallace [3 ]
Karimi, Gholamreza [2 ,4 ]
机构：
[1] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran
[3] Univ S Florida, Coll Publ Hlth, Ctr Environm Occupat Risk Anal & Management, Tampa, FL 33617 USA
[4] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2021年 / 394卷 / 07期
关键词：
Mitochondrial dysfunction; Herat injury; Oxidative stress; Inflammation; Apoptosis; DOXORUBICIN-INDUCED CARDIOTOXICITY; CARDIAC MITOCHONDRIAL DYSFUNCTION; TITANIUM-DIOXIDE NANOPARTICLES; NF-KAPPA-B; OXIDATIVE STRESS; REPRODUCTIVE TOXICITY; INDUCED INFLAMMATION; INDUCED CYTOTOXICITY; MYOCARDIAL TOXICITY; ROS GENERATION;
D O I：
10.1007/s00210-021-02072-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cardiotoxicity is a major adverse effect that can be induced by both therapeutic agents and industrial chemicals. The pathogenesis of such cardiac damage is multifactorial, often injuring the cardiac tissue by generating free radicals, oxidative stress, and/or inflammation. Curcumin (CUR) is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. Administration of CUR has been reported to ameliorate the chemical and drug-induced cardiac injury in several studies. CUR has been suggested to act as an effective candidate against oxidative stress and inflammation in heart tissue via regulation of Nrf2 and suppression of p38 MAPK/NF-kappa B and NLRP3 inflammasomes. The anti-apoptotic properties of CUR have also been reported to modulate the AMPK, Akt, JNK, and ERK signaling pathways. This review explores the potential protective effects of CUR regarding the detrimental effects often observed in cardiac tissue following exposure to several chemicals including drugs.
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收藏
页码：1341 / 1353
页数：13
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