The role of lysosome in regulated necrosis

被引:68
作者
Alu, Aqu [1 ]
Han, Xuejiao [1 ]
Ma, Xuelei [1 ]
Wu, Min [2 ]
Wei, Yuquan [1 ]
Wei, Xiawei [1 ]
机构
[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Lab Aging Res & Canc Drug Target,State Key Lab Bi, Chengdu 610041, Peoples R China
[2] Univ North Dakota, Sch Med & Hlth Sci, Dept Biochem & Mol Biol, Grand Forks, ND 58202 USA
关键词
Ferroptosis; Lysosome; Necroptosis; Pyroptosis; Regulated necrosis; NLRP3 INFLAMMASOME ACTIVATION; NEUTROPHIL EXTRACELLULAR TRAPS; PIGMENT EPITHELIAL-CELLS; ISCHEMIC NEURONAL DEATH; MIXED LINEAGE KINASE; CATHEPSIN-B RELEASE; DOMAIN-LIKE PROTEIN; MEMBRANE PERMEABILIZATION; CANCER-CELLS; OXIDATIVE STRESS;
D O I
10.1016/j.apsb.2020.07.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention. Over the past decades, we largely focused on how lysosome influences apoptosis and autophagic cell death. However, extensive studies showed that lysosome is also prerequisite for the execution of regulated necrosis (RN). Different types of RN have been uncovered, among which, necroptosis, ferroptosis, and pyroptosis are under the most intensive investigation. It becomes a hot topic nowadays to target RN as a therapeutic intervention, since it is important in many patho/physiological settings and contributing to numerous diseases. It is promising to target lysosome to control the occurrence of RN thus altering the outcomes of diseases. Therefore, we aim to give an introduction about the common factors influencing lysosomal stability and then summarize the current knowledge on the role of lysosome in the execution of RN, especially in that of necroptosis, ferroptosis, and pyroptosis. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
引用
收藏
页码:1880 / 1903
页数:24
相关论文
共 318 条
  • [1] Lysosomal cell death at a glance
    Aits, Sonja
    Jaattela, Marja
    [J]. JOURNAL OF CELL SCIENCE, 2013, 126 (09) : 1905 - 1912
  • [2] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice
    Albrengues, Jean
    Shields, Mario A.
    Ng, David
    Park, Chun Gwon
    Ambrico, Alexandra
    Poindexter, Morgan E.
    Upadhyay, Priya
    Uyeminami, Dale L.
    Pommier, Arnaud
    Kuttner, Victoria
    Bruzas, Emilis
    Maiorino, Laura
    Bautista, Carmelita
    Carmona, Ellese M.
    Gimotty, Phyllis A.
    Fearon, Douglas T.
    Chang, Kenneth
    Lyons, Scott K.
    Pinkerton, Kent E.
    Trotman, Lloyd C.
    Goldberg, Michael S.
    Yeh, Johannes T. -H.
    Egeblad, Mikala
    [J]. SCIENCE, 2018, 361 (6409) : 1353 - +
  • [3] HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway
    Aljabri, Abid
    Vijayan, Vijith
    Stankov, Metodi
    Nikolin, Christoph
    Figueiredo, Constanca
    Blasczyk, Rainer
    Becker, Jan Ulrich
    Linkermann, Andreas
    Immenschuh, Stephan
    [J]. CELL DEATH & DISEASE, 2019, 10 (3)
  • [4] Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials
    Andon, Fernando Torres
    Fadeel, Bengt
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (03) : 733 - 742
  • [5] Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
    Andrabi, Shaida A.
    Umanah, George K. E.
    Chang, Calvin
    Stevens, Daniel A.
    Karuppagounder, Senthilkumar S.
    Gagne, Jean-Philippe
    Poirier, Guy G.
    Dawson, Valina L.
    Dawson, Ted M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (28) : 10209 - 10214
  • [6] Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
    Angeli, Jose Pedro Friedmann
    Krysko, Dmitri, V
    Conrad, Marcus
    [J]. NATURE REVIEWS CANCER, 2019, 19 (07) : 405 - 414
  • [7] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
    Angeli, Jose Pedro Friedmann
    Schneider, Manuela
    Proneth, Bettina
    Tyurina, Yulia Y.
    Tyurin, Vladimir A.
    Hammond, Victoria J.
    Herbach, Nadja
    Aichler, Michaela
    Walch, Axel
    Eggenhofer, Elke
    Basavarajappa, Devaraj
    Radmark, Olof
    Kobayashi, Sho
    Seibt, Tobias
    Beck, Heike
    Neff, Frauke
    Esposito, Irene
    Wanke, Ruediger
    Foerster, Heidi
    Yefremova, Olena
    Heinrichmeyer, Marc
    Bornkamm, Georg W.
    Geissler, Edward K.
    Thomas, Stephen B.
    Stockwell, Brent R.
    O'Donnell, Valerie B.
    Kagan, Valerian E.
    Schick, Joel A.
    Conrad, Marcus
    [J]. NATURE CELL BIOLOGY, 2014, 16 (12) : 1180 - U120
  • [8] [Anonymous], 2019, Cancer Discov, V9, pOF2, DOI 10.1158/2159-8290.CD-NB2019-058
  • [9] The lysosome: from waste bag to potential therapeutic target
    Appelqvist, Hanna
    Waster, Petra
    Kagedal, Katarina
    Ollinger, Karin
    [J]. JOURNAL OF MOLECULAR CELL BIOLOGY, 2013, 5 (04) : 214 - 226
  • [10] Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation
    Appelqvist, Hanna
    Nilsson, Cathrine
    Garner, Brett
    Brown, Andrew J.
    Kagedal, Katarina
    Ollinger, Karin
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2011, 178 (02) : 629 - 639