Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance

被引：15
作者：
Augustine, Alicia H. [1 ]
Lowenstein, Lisa M. [1 ]
Harris, William S. [2 ,3 ,4 ]
Shearer, Gregory C. [2 ,3 ,4 ]
Block, Robert C. [1 ,5 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Publ Hlth Sci, Rochester, NY 14642 USA
[2] Sanford Res, Cardiovasc Hlth Res Ctr, Sioux Falls, SD USA
[3] Univ S Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA
[4] Univ S Dakota, Sanford Sch Med, Dept Basic Biomed Sci, Sioux Falls, SD USA
[5] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14627 USA
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2014年 / 90卷 / 2-3期
关键词：
LDL; HDL; VLDL; Fish oil; Nicotinic acid; DHA; EPA; LA; AA; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEINS; PULSE PRESSURE; RISK-FACTOR; FISH-OIL; MORTALITY; NUTRITION;
D O I：
10.1016/j.plefa.2013.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Introduction: The effects of dietary fatty acid supplementation on lipoprotein fatty acid composition have rarely been described. Patients and methods: Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2 g/day extended-release nicotinic acid (ERN), 4 g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. Lipoprotein fatty acid composition was analyzed by gas chromatography pre- and post-treatment. Results: Treatment with P-OM3 or combination, but not ERN, increased proportions of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, and reduced those for arachidonic acid in all lipoprotein fractions, with greatest impact in the high-density lipoprotein fraction. P-OM3-induced changes in eicosapentaenoic acid within low-density lipoproteins and very low-density lipoproteins were associated with beneficial effects on mean arterial pressure and pulse pressure. Conclusions: P-OM3 supplementation, with or without ERN, was associated with differentially altered lipoprotein fatty acid composition and improved blood pressure parameters. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：69 / 75
页数：7
相关论文
共 43 条
  • [1] Overproduction of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome
    Adiels, Martin
    Olofsson, Sven-Olof
    Taskinen, Marja-Riitta
    Boren, Jan
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (07) : 1225 - 1236
  • [2] AGHELI N, 1992, J CLIN BIOCHEM NUTR, V12, P131
  • [3] HDL cholesterol and protective factors in atherosclerosis
    Assmann, G
    Gotto, AM
    [J]. CIRCULATION, 2004, 109 (23) : 8 - 14
  • [4] EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls
    Block, Robert C.
    Harris, William S.
    Reid, Kimberly J.
    Sands, Scott A.
    Spertus, John A.
    [J]. ATHEROSCLEROSIS, 2008, 197 (02) : 821 - 828
  • [5] Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
    Boden, William E.
    Probstfield, Jeffrey L.
    Anderson, Todd
    Chaitman, Bernard R.
    Desvignes-Nickens, Patrice
    Koprowicz, Kent
    McBride, Ruth
    Teo, Koon
    Weintraub, William
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (24) : 2255 - 2267
  • [6] Serum Paraoxonase 1 Activity Is Associated with Fatty Acid Composition of High Density Lipoprotein
    Boshtam, Maryam
    Razavi, Amirnader Emami
    Pourfarzam, Morteza
    Ani, Mohsen
    Naderi, Gholam Ali
    Basati, Gholam
    Mansourian, Marjan
    Dinani, Narges Jafari
    Asgary, Seddigheh
    Abdi, Soheila
    [J]. DISEASE MARKERS, 2013, 2013 : 273 - 280
  • [7] BRAGDON JH, 1961, J LIPID RES, V2, P400
  • [8] N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials
    Bucher, HC
    Hengstler, P
    Schindler, C
    Meier, G
    [J]. AMERICAN JOURNAL OF MEDICINE, 2002, 112 (04) : 298 - 304
  • [9] 15 YEAR MORTALITY IN CORONARY DRUG PROJECT PATIENTS - LONG-TERM BENEFIT WITH NIACIN
    CANNER, PL
    BERGE, KG
    WENGER, NK
    STAMLER, J
    FRIEDMAN, L
    PRINEAS, RJ
    FRIEDEWALD, W
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1986, 8 (06) : 1245 - 1255
  • [10] Reversible flow of cholesteryl ester between high-density lipoproteins and triacylglycerol-rich particles is modulated by the fatty acid composition and concentration of triacylglycerols
    Cazita, P. M.
    Castilho, L. N.
    Carvalho, M. D. T.
    Sesso, A. C.
    Oliveira, H. C. F.
    Quintao, E. C. R.
    [J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2010, 43 (12) : 1135 - 1142
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