Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance

被引：15
作者：
Augustine, Alicia H. [1 ]
Lowenstein, Lisa M. [1 ]
Harris, William S. [2 ,3 ,4 ]
Shearer, Gregory C. [2 ,3 ,4 ]
Block, Robert C. [1 ,5 ]
机构：
[1] Univ Rochester, Med Ctr, Dept Publ Hlth Sci, Rochester, NY 14642 USA
[2] Sanford Res, Cardiovasc Hlth Res Ctr, Sioux Falls, SD USA
[3] Univ S Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA
[4] Univ S Dakota, Sanford Sch Med, Dept Basic Biomed Sci, Sioux Falls, SD USA
[5] Univ Rochester, Med Ctr, Dept Med, Rochester, NY 14627 USA
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2014年 / 90卷 / 2-3期
关键词：
LDL; HDL; VLDL; Fish oil; Nicotinic acid; DHA; EPA; LA; AA; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEINS; PULSE PRESSURE; RISK-FACTOR; FISH-OIL; MORTALITY; NUTRITION;
D O I：
10.1016/j.plefa.2013.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Introduction: The effects of dietary fatty acid supplementation on lipoprotein fatty acid composition have rarely been described. Patients and methods: Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2 g/day extended-release nicotinic acid (ERN), 4 g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. Lipoprotein fatty acid composition was analyzed by gas chromatography pre- and post-treatment. Results: Treatment with P-OM3 or combination, but not ERN, increased proportions of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, and reduced those for arachidonic acid in all lipoprotein fractions, with greatest impact in the high-density lipoprotein fraction. P-OM3-induced changes in eicosapentaenoic acid within low-density lipoproteins and very low-density lipoproteins were associated with beneficial effects on mean arterial pressure and pulse pressure. Conclusions: P-OM3 supplementation, with or without ERN, was associated with differentially altered lipoprotein fatty acid composition and improved blood pressure parameters. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：69 / 75
页数：7
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