HLA-G1 and HLA-G5 isoforms have an additive effect on NK cytolysis

被引：22

作者：

Zhang, Wei-Qun ^{[1
]}

Xu, Dan-Ping ^{[2
]}

Liu, Di ^{[2
]}

Li, Ying-Ying ^{[3
]}

Ruan, Yan-Yun ^{[3
]}

Lin, Aifen ^{[3
]}

Yan, Wei-Hua ^{[2
]}

机构：

[1] Linan Peoples Hosp, Dept Lab Med, Linan 311300, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Med Res Ctr, Linhai 317000, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov, Human Tissue Bank, Linhai 317000, Zhejiang, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2014年 / 75卷 / 02期

基金：

中国国家自然科学基金;

关键词：

LEUKOCYTE ANTIGEN-G; G EXPRESSION; HEPATOCELLULAR-CARCINOMA; CLINICAL-IMPLICATIONS; VIRUS-INFECTION; UP-REGULATION; CELLS; CANCER; METASTASIS; INHIBITION;

D O I：

10.1016/j.humimm.2013.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunotolerant HLA-G could generate seven isoforms including HLA-G1-G7. The suppressive function of either HLA-G1 or HLA-G5 isoform to NK cell cytolysis has been well established. Whether HLA-G1 and HLA-G5 isoform have an additive effect on the cytolysis of NK cells remain to be explored. In this study, effects of expression of HLA-G1 and HLA-G5 isoforms and their combination on NK cytolysis was investigated. NK cell cytolysis was analyzed by detecting the NK cell surface CD107a expression. In this study, data showed that the inhibition capacity is dependent on the level of both HLA-G1 and HLA-G5 expression, but the HLA-G5 isoform has a more potent inhibition effect on the NK cytolysis (p < 0.01). Furthermore, HLA-G1 and HLA-G5 have an additive effect on the suppression of NK cell cytolysis. Our study provided further understanding for the roles of HLA-G1 and HLA-G5 isoform expression in target cells immune escaping from NK cells. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：182 / 189

页数：8

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