Evaluation of proinflammatory cytokine and neopterin levels in women with papillary thyroid carcinoma

被引：19

作者：

Beksac, Kemal ^{[1
]}

Sonmez, Cigdem ^{[2
]}

Cetin, Bahadir ^{[1
]}

Kismali, Gorkem ^{[3
]}

Sel, Tevhide ^{[3
]}

Tuncer, Yildirim ^{[1
]}

Kosova, Funda ^{[4
]}

机构：

[1] Ankara Oncol Hosp, Dept Gen Surg, Mehmet Akif Ersoy Mahallesi 13,Cadde 56, TR-06200 Ankara, Turkey

[2] Ankara Oncol Hosp, Dept Biochem, Ankara, Turkey

[3] Ankara Univ, Dept Biochem, Fac Vet Med, Ankara, Turkey

[4] Celal Bayar Univ, Dept Biochem, Manisa, Turkey

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2016年 / 31卷 / 04期

关键词：

Cytokines; IL-1; beta; IL-6; IL-8; Neopterin; Papillary thyroid cancer; URINARY NEOPTERIN; IMMUNE ACTIVATION; INTERFERON-GAMMA; SERUM NEOPTERIN; INFLAMMATION; CANCER; SURVIVAL; MARKER; INTERLEUKIN-1; INHIBITION;

D O I：

10.5301/jbm.5000214

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: Papillary thyroid cancer is a disease that has been associated with chronic inflammation. The purpose of this study is to measure the production of the proinflammatory cytokines IL-1 beta, IL-6 and IL-8 and neopterin, which is a novel biomarker for cellular immune response in papillary thyroid cancer. Materials and methods: The serum IL-1 beta, IL-6, IL-8 and neopterin values of 31 papillary thyroid cancer patients undergoing bilateral total thyroidectomy were measured before and 20 days after surgery. The values were compared with those of 39 healthy controls. Results: Serum IL-1 beta levels were similar across groups. IL-6 (p<0.001), IL-8 (p = 0.015) and neopterin levels (p = 0.002) were higher in presurgical samples and returned to normal following surgery. Conclusions: The proinflammatory cytokines IL-6 and IL-8, but not IL-1 beta, were produced in greater amounts in papillary thyroid cancer. Serum neopterin seems to be a valid biological marker supporting the presence of papillary thyroid cancer.

引用

页码：E446 / E450

页数：5

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