Islet autoimmunity in phenotypic type 2 diabetes patients

被引：33

作者：

Brooks-Worrell, B. ^{[1
]}

Narla, R. ^{[2
]}

Palmer, J. P. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA USA

[2] VA Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA

来源：

DIABETES OBESITY & METABOLISM | 2013年 / 15卷

关键词：

autoimmune disease; autoimmunity; inflammation; islet-reactive T cells; T cells; type; 1; diabetes; 2; GLUTAMIC-ACID DECARBOXYLASE; T-CELL RESPONSES; CLINICAL PHENOTYPE; ADULTS LADA; LATENT; ANTIBODIES; INFLAMMATION; PROTEINS; MELLITUS; PREDICTION;

D O I：

10.1111/dom.12167

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Historically, type 2 diabetes (T2D) was considered a metabolic disease of ageing. However, recent discoveries have demonstrated the role of chronic systemic inflammation in the development of insulin resistance and subsequent progression to T2D. Over the years, investigations into the pathophysiology of T2D have identified the presence of islet-specific T cells and islet autoimmune disease in T2D patients. Moreover, the cell-mediated islet autoimmunity has also been correlated with the progressive loss of beta-cell function associated with T2D disease pathogenesis. In this manuscript, the involvement of cell-mediated islet autoimmune disease in the progression of T2D disease and the similarities in islet-specific T-cell reactivity between type 1 diabetes (T1D) and T2D are discussed.

引用

页码：137 / 140

页数：4

共 34 条

[1] Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation [J].