Impact of visceral metastases on outcome to abiraterone after docetaxel in castration-resistant prostate cancer patients

被引：19

作者：

Conteduca, Vincenza ^{[1
]}

Caffo, Orazio ^{[2
]}

Fratino, Lucia ^{[3
]}

Lo Re, Giovanni ^{[4
]}

Basso, Umberto ^{[5
]}

D'Angelo, Alessandro ^{[6
]}

Donini, Maddalena ^{[7
]}

Verderame, Francesco ^{[8
]}

Ratta, Raffaele ^{[9
]}

Procopio, Giuseppe ^{[10
]}

Campadelli, Enrico ^{[11
]}

Massari, Francesco ^{[12
]}

Gasparro, Donatello ^{[13
]}

Ermacora, Paola ^{[14
]}

Messina, Caterina ^{[15
]}

Giordano, Monica ^{[16
]}

Alesini, Daniele ^{[17
]}

Zagonel, Vittorina ^{[5
]}

Veccia, Antonello ^{[2
]}

Lolli, Cristian ^{[1
]}

Maines, Francesca ^{[2
]}

De Giorgi, Ugo ^{[1
]}

机构：

[1] Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Meldola, Italy

[2] Santa Chiara Hosp, Trento, Italy

[3] Natl Canc Ctr CRO, Aviano, Italy

[4] Santa Maria Angeli Gen Hosp, Pordenone, Italy

[5] IRCCS, Dept Clin & Expt Oncol, Med Oncol Unit 1, Ist Oncol Veneto, Padua, Italy

[6] S Vincenzo Hosp, Taormina, Italy

[7] Ist Ospitalieri Cremona, Cremona, Italy

[8] Azienda Osped Villa Sofia Cervello, Med Oncol, Palermo, Italy

[9] Campus Biomed Univ Rome, Rome, Italy

[10] Fdn IRCCS, Oncol Unit I, Ist Nazl Tumori, Milan, Italy

[11] Civil Hosp, Lugo Di Romagna, Italy

[12] Inst Gustave Roussy, Villejuif, France

[13] Univ Hosp Parma, Parma, Italy

[14] Azienda Osped Univ, Dipartimento Oncol, Udine, Italy

[15] Pope John Paul XXIII Hosp, Piazza OMS, Med Oncol Unit, Bergamo, Italy

[16] Santa Anna Hosp, Como, Italy

[17] Univ Roma La Sapienza, Div Med Oncol, I-00185 Rome, Italy

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 21期

关键词：

abiraterone acetate; castration-resistant prostate cancer; liver; survival; visceral metastases; MITOXANTRONE PLUS PREDNISONE; 1ST-LINE CHEMOTHERAPY; PROGNOSTIC MODEL; CLINICAL-TRIALS; DOUBLE-BLIND; SURVIVAL; MEN; RECOMMENDATIONS; GUIDELINES; NOMOGRAM;

D O I：

10.2217/fon.15.158

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The objective of this study was to analyze the impact of visceral metastases in castration-resistant prostate cancer (CRPC) treated with abiraterone. Materials & methods: All CRPC patients received abiraterone 1000 mg daily plus prednisone 10 mg orally daily. Liver and lung metastases were considered as visceral metastases. Results: Of 265 CRPC patients, 49 had visceral metastases. Results on progression-free survival were not significantly different in patients with or without visceral metastases. Conversely, the median overall survival between the two groups was 12.4 and 18.5 months (p = 0.01), respectively, and median overall survival of patients with liver-only disease versus other sites was 10.5 versus 18.5 months (p = 0.006), respectively. Conclusion: Visceral disease appears to be an important predictor of clinical outcome in CRPC patients treated with abiraterone.

引用

页码：2881 / 2891

页数：11

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