Asterosaponins and glycosylated polyhydroxysteroids from the starfish Culcita novaeguineae and their cytotoxic activities

被引：20

作者：

Bui Thi Ngoan ^{[1
]}

Tran Thi Hong Hanh ^{[1
]}

Le Thi Vien ^{[1
]}

Chau Ngoc Diep ^{[1
]}

Nguyen Phuong Thao ^{[1
]}

Do Thi Thao ^{[2
]}

Nguyen Van Thanh ^{[1
]}

Nguyen Xuan Cuong ^{[1
]}

Nguyen Hoai Nam ^{[1
]}

Do Cong Thung ^{[3
]}

Phan Van Kiem ^{[1
]}

Kim, Young Ho ^{[4
]}

Chau Van Minh ^{[1
]}

机构：

[1] VAST, Inst Marine Biochem IMBC, Hanoi, Vietnam

[2] VAST, Inst Biotechnol IBT, Hanoi, Vietnam

[3] VAST, IMER, Haiphong, Vietnam

[4] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2015年 / 17卷 / 10期

关键词：

Culcita novaeguineae; Oreasteridae; starfish; novaeguinoside E; cytotoxic activity; STEROIDAL GLYCOSIDES; ASTROPECTEN-POLYACANTHUS; POLAR STEROIDS; SAPONINS; OLIGOGLYCOSIDES; CONSTITUENTS; MONACANTHUS;

D O I：

10.1080/10286020.2015.1041930

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Using combined chromatographic methods, two asterosaponins (compounds 1 and 2), including a new compound novaeguinoside E (compound 1), and six glycosylated polyhydroxysteroids (compounds 3-8) were isolated from a methanol extract of the starfish Culcita novaeguineae. Their structures were determined on the basis of spectroscopic data (H-1 and C-13 NMR, HSQC, HMBC, H-1-H-1 COSY, ROESY, and HRESI-MS) and by comparison with the literature values. The new compound 1 represents the third example of asterosaponins containing the 5-cholesta-9(1l)-en-3,6,20,22-tetraol aglycone. Among isolated compounds, 4-7 exhibited moderate to weak cytotoxic activities against five human cancer cell lines such as Hep-G2 (hepatoma), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma).

引用

收藏

页码：1010 / 1017

页数：8

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