Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

被引：37

作者：

Isaev, N. K. ^{[1
,2
]}

Stelmashook, E. V. ^{[2
]}

Plotnikov, E. Y. ^{[1
]}

Khryapenkova, T. G. ^{[1
]}

Lozier, E. R. ^{[3
]}

Doludin, Y. V. ^{[3
]}

Silachev, D. N. ^{[1
]}

Zorov, D. B. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[2] Russian Acad Med Sci, Brain Res Dept, Sci Ctr Neurol, Moscow 105064, Russia

[3] Moscow MV Lomonosov State Univ, Fac Bioengn & Bioinformat, Moscow 119992, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

acidosis; neurons; ischemia; hypoxia; pH; ASIC1a;

D O I：

10.1134/S0006297908110011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.

引用

页码：1171 / 1175

页数：5

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