Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

被引：37

作者：

Isaev, N. K. ^{[1
,2
]}

Stelmashook, E. V. ^{[2
]}

Plotnikov, E. Y. ^{[1
]}

Khryapenkova, T. G. ^{[1
]}

Lozier, E. R. ^{[3
]}

Doludin, Y. V. ^{[3
]}

Silachev, D. N. ^{[1
]}

Zorov, D. B. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[2] Russian Acad Med Sci, Brain Res Dept, Sci Ctr Neurol, Moscow 105064, Russia

[3] Moscow MV Lomonosov State Univ, Fac Bioengn & Bioinformat, Moscow 119992, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2008年 / 73卷 / 11期

基金：

俄罗斯基础研究基金会;

关键词：

acidosis; neurons; ischemia; hypoxia; pH; ASIC1a;

D O I：

10.1134/S0006297908110011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.

引用

页码：1171 / 1175

页数：5

共 55 条

[1] Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation [J].

Almaas, R ;

Pytte, M ;

Lindstad, JK ;

Wright, M ;

Saugstad, OD ;

Pleasure, D ;

Rootwelt, T .

JOURNAL OF NEUROCHEMISTRY, 2003, 84 (05) :1018-1027

[2] 5-(N-ETHYL-N-ISOPROPYL)AMILORIDE AND MILD ACIDOSIS PROTECT CULTURED CEREBEL LAR GRANULE CELLS AGAINST GLUTAMATE-INDUCED DELAYED NEURONAL DEATH [J].

ANDREEVA, N ;

KHODOROV, B ;

STELMASHOOK, E ;

SOKOLOVA, S ;

CRAGOE, E ;

VICTOROV, I .

NEUROSCIENCE, 1992, 49 (01) :175-181

[3] Regulation of intracellular pH [J].

Boron, WF .

ADVANCES IN PHYSIOLOGY EDUCATION, 2004, 28 (04) :160-179

[4] METABOLIC-REGULATION VIA INTRACELLULAR PH [J].

BUSA, WB ;

NUCCITELLI, R .

AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (04) :R409-R438

[5] Physico-chemical occurences during the development of egg - I Measuring of the concentration of hydrogen ions [J].

Buytendijk, FJJ ;

Woerdeman, MW .

WILHELM ROUX ARCHIV FUR ENTWICKLUNGSMECHANIK DER ORGANISMEN, 1927, 112 :387-410

[6] A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a [J].

Chai, Sunghee ;

Li, Minghua ;

Lan, JingQuan ;

Xiong, Zhi-Gang ;

Saugstad, Julie A. ;

Simon, Roger P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (31) :22668-22677

[7]

CHOI DW, 1990, J NEUROSCI, V10, P2493

[8] Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system [J].

de la Rosa, DA ;

Krueger, SR ;

Kolar, A ;

Shao, D ;

Fitzsimonds, RM ;

Canessa, CM .

JOURNAL OF PHYSIOLOGY-LONDON, 2003, 546 (01) :77-87

[9] Acidosis induces necrosis and apoptosis of cultured hippocampal neurons [J].

Ding, D ;

Moskowitz, SI ;

Li, R ;

Lee, SB ;

Esteban, M ;

Tomaselli, K ;

Chan, J ;

Bergold, PJ .

EXPERIMENTAL NEUROLOGY, 2000, 162 (01) :1-12

[10] Effect of low pH on glutamate uptake and release in isolated presynaptic endings from rat brain [J].

Fedorovich, SV ;

Kaler, GV ;

Konev, SV .

NEUROCHEMICAL RESEARCH, 2003, 28 (05) :715-721

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