Synthesis of novel bis-anthraquinone derivatives and their biological evaluation as antitumor agents

被引：8
作者：
Taher, Azza T. [1 ,2 ]
Hegazy, Gehan H. [3 ]
机构：
[1] Cairo Univ, Dept Pharmaceut Organ Chem, Fac Pharm, Cairo, Egypt
[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt
[3] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 05期
关键词：
Anticancer; DNA; Bis-anthraquinone derivatives; NATIONAL-CANCER-INSTITUTE; DNA-BINDING; DRUG DISCOVERY; CYTOTOXICITY; MODE;
D O I：
10.1007/s12272-013-0074-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cancer has become a major worldwide problem and drug resistance now is one of the most important problems in treatment of cancer. Anthraquinone derivatives represent one of the most important drugs that can be used in treatment of many types of cancer. In this study two series of novel bis-anthraquinone derivatives have been synthesized. Five of these compounds were chosen to be evaluated for their antitumor activity against human cancer cell lines by the National Cancer Institute (NCI, USA). Marked activity was shown for the tested compounds(2-6). The most active one was compound 6 with mean value -67.00 against all cell lines. Compounds 7 and 8 were found inactive. .
引用
收藏
页码：573 / 578
页数：6
相关论文
共 50 条
[41]   Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran-pyrazole derivatives as anticancer agents [J].
Abd El-Karim, Somaia S. ;
Anwar, Manal M. ;
Mohamed, Neama A. ;
Nasr, Tamer ;
Elseginy, Samia A. .
BIOORGANIC CHEMISTRY, 2015, 63 :1-12
[42]   Synthesis, biological evaluation and preliminary mechanisms of 6-amino substituted harmine derivatives as potential antitumor agents [J].
Hu, Dongyan ;
Han, Guangtian ;
Ren, Huazhong ;
Li, Xinwei ;
Li, Xi'an ;
Yue, Lirong ;
Xu, Jiao ;
Feng, Jiafu ;
Guo, Li .
FITOTERAPIA, 2022, 163
[43]   Synthesis of new 1,3,4-benzotriazepin-5-one derivatives and their biological evaluation as antitumor agents [J].
Taher, Azza T. ;
Mohammed, Lamia W. .
ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (06) :684-693
[44]   Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents [J].
Amin, Kamilia M. ;
Eissa, Amal A. M. ;
Abou-Seri, Sahar M. ;
Awadallah, Fadi M. ;
Hassan, Ghaneya S. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 60 :187-198
[45]   Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents [J].
Wang, Jianhong ;
Xie, Songqiang ;
Li, Yanjie ;
Guo, Yongjun ;
Ma, Yuanfang ;
Zhao, Jin ;
Phanstiel, Otto ;
Wang, Chaojie .
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (14) :7005-7012
[46]   Synthesis of obovatol derivatives and their preliminary evaluation as antitumor agents [J].
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea, Republic of ;
不详 ;
不详 .
Bull. Korean Chem. Soc., 2007, 9 (1601-1604) :1601-1604
[47]   Synthesis and biological evaluation of indolyl chalcones as antitumor agents [J].
Kumar, Dalip ;
Kumar, N. Maruthi ;
Akamatsu, Kanako ;
Kusaka, Eriko ;
Harada, Hiroshi ;
Ito, Takeo .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (13) :3916-3919
[48]   Synthesis of obovatol derivatives and their preliminary evaluation as antitumor agents [J].
Lee, Mi-Sung ;
Yang, Jung-Eun ;
Choi, Eun-Hwa ;
In, Jin-Kyung ;
Lee, So Yong ;
Lee, Heesoon ;
Hong, Jin Tae ;
Lee, Hyo Won ;
Suh, Young-Ger ;
Jung, Jae-Kyung .
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2007, 28 (09) :1601-1604
[49]   Synthesis and Biological Evaluation of Novel 1-Alkyltryptophan Analogs as Potential Antitumor Agents [J].
Sun, Ting ;
Li, Zhao-Long ;
Tian, Hua ;
Wang, Shih-Chen ;
Cai, Jiong .
MOLECULES, 2009, 14 (12) :5339-5348
[50]   Synthesis and biological evaluation of novel cyclic enediyne compounds related to dynemicin A as antitumor agents [J].
Unno, R ;
Michishita, H ;
Inagaki, H ;
Baba, Y ;
Jomori, T ;
Nishikawa, T ;
Isobe, M .
CHEMICAL & PHARMACEUTICAL BULLETIN, 1997, 45 (01) :125-133
12345