Association Between the XRCC3 T241M Polymorphism and Head and Neck Cancer Susceptibility: a Meta-analysis of Case-control Studies

被引：18

作者：

Yin, Qing-Hua ^{[1
,2
]}

Liu, Chuan ^{[3
]}

Li, Lian ^{[1
]}

Zu, Xu-Yu ^{[4
]}

Wang, Ya-Jie ^{[3
]}

机构：

[1] Yueyang Second Peoples Hosp, Yueyang, Peoples R China

[2] Univ S China, Affiliated Hosp 1, Dept Med Oncol, Hengyang, Peoples R China

[3] Second Mil Med Univ, Changhai Hosp, Dept Oncol, Shanghai, Peoples R China

[4] Univ S China, Affiliated Hosp 1, Shanghai, Peoples R China

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 10期

关键词：

Meta-analysis; head and neck cancer; XRCC3; DNA-REPAIR GENE; SQUAMOUS-CELL CARCINOMA; SINGLE-NUCLEOTIDE POLYMORPHISMS; UPPER AERODIGESTIVE TRACT; HOMOLOGY-DIRECTED REPAIR; POOLED ANALYSIS; RISK; VARIANT; BREAKS; TUMORS;

D O I：

10.7314/APJCP.2012.13.10.5201

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To evaluate the role of the X-ray repair cross complementing group 3 (XRCC3) T241M polymorphism in head and neck cancer susceptibility. Materials and Methods: We performed a meta-analysis of all available studies, which included 3,191 cases and 5,090 controls. Results: Overall, a significant risk effect of the T241M polymorphism was not found under homologous contrast (MM vs TT: OR=1.293, 95% CI=0.926-1.805; TM vs TT: OR=1.148 95% CI=0.930-1.418) and recessive models (MM vs TT+TM): OR=1.170, 95% CI=0.905-1.512, but a significantly increased risk was observed under a dominant model (MM+TM vs TT): OR=1.243, 95% CI=1.001-1.544. In stratified analyses, there were no significant associations for Asians or Caucasians. Conclusion: Our meta-analysis suggested the XRCC3 241M allele (MM+TM) might act as a head and neck cancer risk factor among all subjects, and the effect of T241M polymorphism on head and neck susceptibility should be studied with a larger, stratified population.

引用

页码：5201 / 5205

页数：5