A Fas agonist induces high levels of apoptosis in haematological malignancies

被引：35
作者：
Greaney, P
Nahimana, A
Lagopoulos, L
Etter, AL
Aubry, D
Attinger, A
Beltraminelli, N
Huni, B
Bassi, I
Sordat, B
Demotz, S
Dupuis, M
Duchosal, MA
机构：
[1] Univ Lausanne Hosp, CHU Vaudois, Serv Hematol, CH-1011 Lausanne, Switzerland
[2] Apoxis SA, CH-1004 Lausanne, Switzerland
来源：
LEUKEMIA RESEARCH | 2006年 / 30卷 / 04期
关键词：
apoptosis; cytotoxicity; Fas; haematological malignancies; cancer;
D O I：
10.1016/j.leukres.2005.08.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We developed and tested a potent hexameric Fas agonist, termed MegaFasL, for its cytotoxic effects on a panel of human haematopoietic malignant cells and healthy human haematopoietic progenitor cells (CD34+CD38low). Results demonstrated that MegaFasL induced apoptosis in cell lines and primary cells representing multiple myeloma (MM), acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL) and Burkitt's lymphoma. Cells from a chronic myeloid leukaemia (CML) line and from patients with chronic lymphocytic leukaemia (CLL) were resistant. Furthermore, CD34+CD38low progenitor cells were also resistant to MegaFasL. The data indicate that MegaFasL could be a highly efficient therapeutic agent ex vivo or potentially in vivo. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：415 / 426
页数：12
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