Impact of Lymphadenectomy on Survival of Patients with Serous Advanced Ovarian Cancer After Neoadjuvant Chemotherapy: A French National Multicenter Study (FRANCOGYN)

被引：17

作者：

Bund, Virginie ^{[1
,2
]}

Lecointre, Lise ^{[1
,3
,4
]}

Velten, Michel ^{[2
]}

Ouldamer, Lobna ^{[5
]}

Bendifallah, Sofiane ^{[6
]}

Koskas, Martin ^{[7
]}

Bolze, Pierre-Adrien ^{[8
]}

Collinet, Pierre ^{[9
]}

Canlorbe, Geoffroy ^{[10
]}

Touboul, Cyril ^{[11
]}

Huchon, Cyrille ^{[12
]}

Coutant, Charles ^{[13
]}

Faller, Emilie ^{[1
]}

Boisrame, Thomas ^{[1
]}

Gantzer, Justine ^{[14
]}

Demarchi, Martin ^{[15
]}

Baldauf, Jean-Jacques ^{[1
]}

Ballester, Marcos ^{[16
]}

Lavoue, Vincent ^{[17
]}

Akladios, Cherif ^{[1
]}

机构：

[1] Hop Univ Strasbourg, Dept Gynecol Surg, F-67091 Strasbourg, France

[2] Hop Univ Strasbourg, Dept Publ Hlth, F-67091 Strasbourg, France

[3] Univ Strasbourg, I Cube UMR 7357, Lab Sci Ingenieur Informat & Imagerie, F-67081 Strasbourg, France

[4] Univ Strasbourg, Inst Hospitalo Univ IHU, Inst Minimally Invas Hybrid Image Guided Surg, F-67081 Strasbourg, France

[5] Hop Univ Tours, Dept Gynecol, F-37000 Tours, France

[6] Hop Tenon, AP HP, Dept Gynaecol & Obstet, F-75020 Paris, France

[7] Hop Bichat Claude Bernard, AP HP, Dept Gynecol, F-75018 Paris, France

[8] CHU Lyon Sud, Gynecol Surg Serv, F-69000 Lyon, France

[9] CHRU, Hop Jeanne De Flandre, Dept Gynecol Surg, F-59000 Lille, France

[10] Hop La Pitie Salpetriere, AP HP, Dept Gynecol & Breast Surg & Oncol, F-75013 Paris, France

[11] Ctr Hosp Intercommunal, Dept Obstet & Gynaecol, F-94000 Creteil, France

[12] Ctr Hosp Poissy, Dept Gynecol, F-78100 Poissy, France

[13] Georges Francois Leclerc Canc Ctr, Dept Surg Oncol, F-21000 Dijon, France

[14] Hop Univ Strasbourg, Dept Med Oncol, F-67091 Strasbourg, France

[15] Ctr Paul Strauss, Med Oncol Dept, F-67000 Strasbourg, France

[16] Grp Hosp Diaconesses Croix, Dept Gynecol & Breast Surg, F-75020 Paris, France

[17] Hop Univ Rennes, Dept Gynecol Surg, F-35000 Rennes, France

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 08期

关键词：

ovarian carcinoma; neoadjuvant chemotherapy; systematic lymphadenectomy; INTERVAL DEBULKING SURGERY; LYMPH-NODE INVOLVEMENT; STAGE-IV OVARIAN; SYSTEMATIC LYMPHADENECTOMY; RETROPERITONEAL LYMPHADENECTOMY; PARAAORTIC LYMPHADENECTOMY; PROGNOSTIC-SIGNIFICANCE; CYTOREDUCTIVE SURGERY; MANAGEMENT; RESECTION;

D O I：

10.3390/jcm9082427

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The population of interest to this study comprised individuals with advanced-stage ovarian carcinoma who were exposed to neoadjuvant chemotherapy (NAC) followed by interval debulking surgery (IDS). Those who had not received systematic lymphadenectomy (SL; Group 1) were compared to those who had received SL (Group 2). Outcome measures included progression-free survival (PFS), overall survival (OS), and surgical complications. Methods: This was a retrospective, multicenter cohort study in nine referral centers of France between January 2000 and June 2017. OS analysis using the multivariate Cox regression model was performed. PFS and surgery-related morbidity were analyzed. Results: Of the 255 patients included, 100 were in Group 1 and 155 in Group 2. Patient majority was, on average, younger and less comorbid, with predominant R0 surgery in Group 2. Dindo-Clavien score was similar between the two groups (p= 0.15). Median OS was 26.8 months in Group 2 and 27.6 months in Group 1. SL was not statistically significant on OS (p= 0.7). Median PFS was 18.3 months in Group 2 and 16.6 months in Group 1. SL had positive impact on PFS (p= 0.005). Conclusions: patients who had received SL (Group 2) had significantly higher PFS regardless of node-positivity status when compared to those who had not received SL (Group 1).

引用

页码：1 / 17

页数：16

共 47 条

[1] Role of lymphadenectomy in the management of grossly apparent advanced stage epithelial ovarian cancer [J].