Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma

被引：34

作者：

Ch'ng, Sydney ^{[1
]}

Clark, Jonathan R. ^{[1
]}

Brunner, Markus ^{[1
]}

Palme, Carsten E. ^{[2
]}

Morgan, Gary J. ^{[2
]}

Veness, Michael J. ^{[2
]}

机构：

[1] Royal Prince Alfred Hosp, Sydney Head & Neck Canc Inst, Sydney, NSW, Australia

[2] Univ Sydney, Westmead Hosp, Head & Neck Canc Serv, Sydney, NSW 2006, Australia

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 02期

关键词：

staging; cutaneous squamous cell carcinoma; tumor factor; tumor differentiation; PERINEURAL INVASION; NECK; HEAD; SKIN; SURVIVAL;

D O I：

10.1002/hed.22941

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. It remains unclear how primary tumor factors impact on prognosis in patients with nodal metastasis in head and neck cutaneous squamous cell carcinoma (SCC). The purpose of this study was to assess whether primary tumor characteristics are independent prognostic factors. Methods. Patients treated for metastatic cutaneous SCC from 1978 to 2010 were identified (n = 239). A proportional hazards model was used to assess the effect of primary tumor variables. Results. On multivariable analysis, tumor differentiation (hazard ratio [HR], 0.2; 95% confidence interval [CI], 0.1-0.8; p = .03) was found to be significantly associated with disease-specific survival (DSS), unlike margin status (p = .23), tumor size (p = .21), and thickness (p = .11). Patient, treatment, and nodal factors were confirmed to be important predictors of survival. Conclusion. This article suggests that pathological features of the primary lesion bear little importance in the presence of established nodal metastasis, other than tumor differentiation. It validates the grouping of T1-3N1 as stage III under the current American Joint Committee on Cancer (AJCC) TNM staging system. (C) 2012 Wiley Periodicals, Inc. Head Neck 35: 190-194, 2013

引用

页码：190 / 194

页数：5

共 14 条

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