TB database: an integrated platform for tuberculosis research

被引：177

作者：

Reddy, T. B. K. ^{[1
]}

Riley, Robert ^{[2
]}

Wymore, Farrell ^{[1
]}

Montgomery, Phillip ^{[2
]}

DeCaprio, Dave ^{[2
]}

Engels, Reinhard ^{[2
]}

Gellesch, Marcel ^{[2
]}

Hubble, Jeremy ^{[3
]}

Jen, Dennis ^{[2
]}

Jin, Heng ^{[1
]}

Koehrsen, Michael ^{[2
]}

Larson, Lisa ^{[2
]}

Mao, Maria ^{[3
]}

Nitzberg, Michael ^{[1
]}

Sisk, Peter ^{[2
]}

Stolte, Christian ^{[2
]}

Weiner, Brian ^{[2
]}

White, Jared ^{[2
]}

Zachariah, Zachariah K. ^{[1
]}

Sherlock, Gavin ^{[3
]}

Galagan, James E. ^{[2
,4
,5
]}

Ball, Catherine A. ^{[1
]}

Schoolnik, Gary K. ^{[6
]}

机构：

[1] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA

[2] MIT & Harvard, Broad Inst, Cambridge, MA 02142 USA

[3] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[4] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[5] Boston Univ, Natl Emerging Infect Dis Lab, Boston, MA 02118 USA

[6] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

MYCOBACTERIUM-TUBERCULOSIS; GENOME SEQUENCE; GENES; SOFTWARE; BIOLOGY; TOOLS;

D O I：

10.1093/nar/gkn652

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effective control of tuberculosis (TB) has been thwarted by the need for prolonged, complex and potentially toxic drug regimens, by reliance on an inefficient vaccine and by the absence of biomarkers of clinical status. The promise of the genomics era for TB control is substantial, but has been hindered by the lack of a central repository that collects and integrates genomic and experimental data about this organism in a way that can be readily accessed and analyzed. The Tuberculosis Database (TBDB) is an integrated database providing access to TB genomic data and resources, relevant to the discovery and development of TB drugs, vaccines and biomarkers. The current release of TBDB houses genome sequence data and annotations for 28 different Mycobacterium tuberculosis strains and related bacteria. TBDB stores pre- and post-publication gene-expression data from M. tuberculosis and its close relatives. TBDB currently hosts data for nearly 1500 public tuberculosis microarrays and 260 arrays for Streptomyces. In addition, TBDB provides access to a suite of comparative genomics and microarray analysis software. By bringing together M. tuberculosis genome annotation and gene-expression data with a suite of analysis tools, TBDB (http://www.tbdb.org/) provides a unique discovery platform for TB research.

引用

页码：D499 / D508

页数：10

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