Neuroendocrine mechanisms in fibromyalgiachronic fatigue

被引：30

作者：

Buskila, D

Press, J

机构：

[1] Soroka Med Ctr, Rheumat Dis Unit, IL-84101 Beer Sheva, Israel

[2] Soroka Med Ctr, Dept Med B, IL-84101 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, IL-84101 Beer Sheva, Israel

[4] Soroka Med Ctr, Div Paediat, IL-84101 Beer Sheva, Israel

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2001年 / 15卷 / 05期

关键词：

fibromyalgia; chronic fatigue syndrome; neuroendocrine dysregulation; central sensitization; dysautonomia; treatment;

D O I：

10.1053/berh.2001.0191

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibromyalgia and chronic fatigue syndrome are poorly understood disorders that share similar demographic and clinical characteristics. Because of the clinical similarities between both disorders it was suggested that they share a common pathophysiological mechanism, namely, central nervous system dysfunction. This chapter presents data demonstrating neurohormonal abnormalities, abnormal pain processing and autonomic nervous system dysfunction in fibromyalgia and chronic fatigue syndrome. The possible contribution of the central nervous system dysfunction to the development and symptomatology of these conditions is discussed. The chapter concludes by reviewing the effect of current treatments and emerging therapeutic modalities in fibromyalgia and chronic fatigue syndrome.

引用

页码：747 / 758

页数：12

共 92 条

[1] Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome [J].