Amino acids/peptides conjugated heterocycles: A tool for the recent development of novel therapeutic agents

被引：77
作者：
Wang, Meng [1 ]
Rakesh, K. P. [1 ]
Leng, Jing [1 ]
Fang, Wan-Yin [1 ]
Ravindar, L. [1 ]
Gowda, D. Channe [2 ]
Qin, Hua-Li [1 ]
机构：
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Pharmaceut Engn, 205 Luoshi Rd, Wuhan 430073, Hubei, Peoples R China
[2] Univ Mysore, Dept Studies Chem, Mysuru 570006, Karnataka, India
来源：
BIOORGANIC CHEMISTRY | 2018年 / 76卷
基金：
中国国家自然科学基金;
关键词：
Amino acids; Peptides; Conjugation; Heterocycles; Biological activities; SAR; H+/K+-ATPASE INHIBITORS; IN-VITRO; UREA/THIOUREA DERIVATIVES; STREPTOCOCCUS-PNEUMONIAE; ANTIINFLAMMATORY AGENTS; ANTIFUNGAL ACTIVITIES; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY; MOLECULAR DOCKING; PROTEIN GLYCATION;
D O I：
10.1016/j.bioorg.2017.11.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future. In this review, we discuss and highlight the recent findings of the structural features that encourage biological applications of amino acid/peptides based conjugates. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：113 / 129
页数：17
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