The concentration of adiponectin in breast milk is related to maternal hormonal and inflammatory status during 6 months of lactation

被引:30
作者
Ozarda, Yesim [1 ]
Gunes, Yeliz [1 ]
Tuncer, Gul Ozlem [1 ]
机构
[1] Uludag Univ, Sch Med, Dept Biochem, TR-16059 Gorukle, Bursa, Turkey
关键词
adiponectin; breastfed infants milk; lactation; serum cortisol; serum prolactin; serum thyroxine; C-REACTIVE PROTEIN; ADIPOSE-TISSUE; HUMAN ADIPOCYTES; BIRTH-WEIGHT; CORD BLOOD; LEPTIN; SERUM; EXPRESSION; GHRELIN; ADIPOKINES;
D O I
10.1515/cclm-2011-0724
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Varying concentrations of adiponectin are present in human breast milk. This study aimed to determine the relationship between milk adiponectin concentration and the hormonal and inflammatory status of breast-feeding women. Methods: Blood and breast milk samples were collected from 157 breast-feeding women enrolled at 1-180 post-partum lactation days. The milk and serum adiponectin concentrations were measured by radioimmunoassays. The serum oestradiol, prolactin, thyroxine, triiodothyronine, cortisol and insulin concentrations were measured by the chemiluminescent immunometric method. The leptin, resistin and ghrelin concentrations were measured by the immunometric methods. Results: The milk, but not serum, adiponectin concentration increased during the 180-day lactation period and displayed a positive correlation (r=0.748; p<0.001) to the lactation day. The milk adiponectin concentration was positively correlated to the maternal serum ghrelin concentration (r=0.299; p<0.001) and inversely to the maternal serum oestradiol (r=-0.366; p<0.001), prolactin (r=-0.444; p<0.001), thyroxine (r=-0.355; p<0.001), triiodothyronine (r=-0.291; p<0.001), cortisol (r=-0.537; p<0.001), and C-reactive protein (r=-0.483; p<0.001) concentrations. The milk adiponectin concentration was positively correlated to the milk leptin (r=0.344; p<0.001) and ghrelin (r=0.458; p<0.001) concentrations, and inversely to milk resistin concentration (r=-0.518; p<0.001). The serum adiponectin concentration in breastfed infants was positively correlated (r=0.711; p<0.001) to the adiponectin concentration in the consumed breast milk. Conclusions: The adiponectin concentration in breast milk increases over time during lactation and is affected by the maternal hormonal and inflammatory status.
引用
收藏
页码:911 / 917
页数:7
相关论文
共 37 条
[1]   Hypoadiponectinemia in lean lactating women: Prolactin inhibits adiponectin secretion from human adipocytes [J].
Asai-Sato, Mikiko ;
Okamoto, Machi ;
Endo, Masaya ;
Yoshida, Hiroshi ;
Murase, Mariko ;
Ikeda, Mario ;
Sakakibara, Hideya ;
Takahashi, Tsuneo ;
Hirahara, Fumiki .
ENDOCRINE JOURNAL, 2006, 53 (04) :555-562
[2]   The role of adipocytokines in fetal growth [J].
Briana, Despina D. ;
Malamitsi-Puchner, Ariadne .
WOMEN'S HEALTH AND DISEASE, 2010, 1205 :82-87
[3]   Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein:: Proteins newly identified in human breast milk [J].
Bronsky, Jiri ;
Karpisek, Michal ;
Bronska, Eva ;
Pechova, Marta ;
Janicikova, Barbora ;
Kotolova, Hana ;
Stejskal, David ;
Prusa, Richard ;
Nevoral, Jiri .
CLINICAL CHEMISTRY, 2006, 52 (09) :1763-1770
[4]   Adiponectin, AFABP, and Leptin in Human Breast Milk During 12 Months of Lactation [J].
Bronsky, Jiri ;
Mitrova, Katarina ;
Karpisek, Michal ;
Mazoch, Jiri ;
Durilova, Marianna ;
Fisarkova, Barbora ;
Stechova, Katerina ;
Prusa, Richard ;
Nevoral, Jiri .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2011, 52 (04) :474-477
[5]   Effect of Triiodothyronine on Adiponectin Expression and Leptin Release by White Adipose Tissue of Normal Rats [J].
Cabanelas, A. ;
Cordeiro, A. ;
dos Santos Almeida, N. A. ;
Monteiro de Paula, G. S. ;
Coelho, V. M. ;
Ortiga-Carvalho, T. M. ;
Pazos-Moura, C. C. .
HORMONE AND METABOLIC RESEARCH, 2010, 42 (04) :254-260
[6]  
De Meeus J. B., 1998, Clinical and Experimental Obstetrics and Gynecology, V25, P9
[7]   Regulation of adiponectin expression in human adipocytes:: Effects of adiposity, glucocorticoids, and tumor necrosis factor α [J].
Degawa-Yamauchi, M ;
Moss, KA ;
Bovenkerk, JE ;
Shankar, SS ;
Morrison, CL ;
Lelliott, CJ ;
Vidal-Puig, A ;
Jones, R ;
Considine, RV .
OBESITY RESEARCH, 2005, 13 (04) :662-669
[8]   C-REACTIVE PROTEIN AND SERUM AMYLOID-A PROTEIN IN PREGNANCY AND LABOR [J].
DEVILLIERS, WJ ;
LOUW, JP ;
STRACHAN, AF ;
ETSEBETH, SM ;
SHEPHARD, EG ;
DEBEER, FC .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1990, 97 (08) :725-730
[9]   Ghrelin and adiponectin levels in colostrum, cord blood and maternal serum [J].
Dundar, Nihal O. ;
Dundar, Bumin ;
Cesur, Goekhan ;
Yilmaz, Nigar ;
Sutcu, Recep ;
Ozguner, Fehmi .
PEDIATRICS INTERNATIONAL, 2010, 52 (04) :622-625
[10]   The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity [J].
Dyck, DJ ;
Heigenhauser, GJF ;
Bruce, CR .
ACTA PHYSIOLOGICA, 2006, 186 (01) :5-16