Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

被引:92
作者
Fletcher, Steven [1 ]
Turkson, James [2 ]
Gunning, Patrick T. [1 ]
机构
[1] Univ Toronto, Dept Chem, Mississauga, ON L5L 1C6, Canada
[2] Univ Cent Florida, Burnett Coll Biomed Sci, Dept Mol Biol & Microbiol, Orlando, FL 32826 USA
关键词
antitumor agents; peptidomimetics; protein-protein interactions; small molecules; stat3;
D O I
10.1002/cmdc.200800123
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1159 / 1168
页数:10
相关论文
共 53 条
[1]   Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer - Modern target but ancient solution [J].
Aggarwal, Bharat B. ;
Sethi, Gautam ;
Ahn, Kwang Seok ;
Sandur, Santosh K. ;
Pandey, Manoj K. ;
Kunnumakkara, Ajaikumar B. ;
Sung, Bokyung ;
Ichikawa, Haruyo .
SIGNAL TRANSDUCTION PATHWAYS, PT B: STRESS SIGNALING AND TRANSCRIPTIONAL CONTROL, 2006, 1091 :151-169
[2]  
Barton BE, 2004, MOL CANCER THER, V3, P11
[3]   Three-dimensional structure of the Stat3β homodimer bound to DNA [J].
Becker, S ;
Groner, B ;
Müller, CW .
NATURE, 1998, 394 (6689) :145-151
[4]   Signal transducers and activators of transcription as targets for small organic molecules [J].
Berg, Thorsten .
CHEMBIOCHEM, 2008, 9 (13) :2039-2044
[5]   Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer [J].
Berishaj, Marjan ;
Gao, Sizhi Paul ;
Ahmed, Simi ;
Leslie, Kenneth ;
Al-Ahmadie, Hikmat ;
Gerald, William L. ;
Bornmann, William ;
Bromberg, Jacqueline F. .
BREAST CANCER RESEARCH, 2007, 9 (03)
[6]   Biomolecular Targets for Platinum Antitumor Drugs [J].
Bose, Rathindra N. .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2002, 2 (02) :103-111
[7]   STATs in oncogenesis [J].
Bowman, T ;
Garcia, R ;
Turkson, J ;
Jove, R .
ONCOGENE, 2000, 19 (21) :2474-2488
[8]  
Buettner R, 2002, CLIN CANCER RES, V8, P945
[9]   Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells [J].
Burke, WM ;
Jin, XH ;
Lin, HJ ;
Huang, M ;
Liu, R ;
Reynolds, RK ;
Lin, JY .
ONCOGENE, 2001, 20 (55) :7925-7934
[10]  
CAILLEAU R, 1978, IN VITRO CELL DEV B, V14, P911