Genetic Diversity of O-Antigen Biosynthesis Regions in Vibrio cholerae

被引：26

作者：

Aydanian, Antonina ^{[1
,2
]}

Tang, Li ^{[1
]}

Morris, J. Glenn ^{[3
]}

Johnson, Judith A. ^{[3
,4
]}

Stine, O. Colin ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA

[2] US FDA, Bethesda, MD 20014 USA

[3] Univ Florida, Coll Med, Emerging Pathogens Inst, Gainesville, FL USA

[4] Univ Florida, Coll Med, Dept Pathol, Gainesville, FL USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2011年 / 77卷 / 07期

基金：

美国国家卫生研究院;

关键词：

POLYSACCHARIDE PORTION; SUGAR COMPOSITION; O139; SEQUENCE; LIPOPOLYSACCHARIDES; NON-O1; BACTERIOPHAGE; EVOLUTION; CORRELATE; DIARRHEA;

D O I：

10.1128/AEM.01663-10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

O-antigen biosynthetic (wbf) regions for Vibrio cholerae serogroups O5, O8, and O108 were isolated and sequenced. Sequences were compared to those of other published V. cholerae O-antigen regions. These wbf regions showed a high degree of heterogeneity both in gene content and in gene order. Genes identified frequently showed greater similarities to polysaccharide biosynthesis genes from species other than V. cholerae. Our results demonstrate the plasticity of O-antigen genes in V. cholerae, the diversity of the genetic pool from which they are drawn, and the likelihood that new pandemic serogroups will emerge.

引用

页码：2247 / 2253

页数：7

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