Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation

被引：136

作者：

Ikarashi, Nobutomo ^{[1
]}

Kon, Risako ^{[1
]}

Sugiyama, Kiyoshi ^{[1
]}

机构：

[1] Hoshi Univ, Dept Clin Pharmacokinet, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 07期

基金：

日本学术振兴会;

关键词：

aquaporin; colon; diarrhea; laxative; constipation; morphine; RAT GASTROINTESTINAL-TRACT; VASOACTIVE INTESTINAL POLYPEPTIDE; WATER CHANNEL; MAGNESIUM-SULFATE; DOWN-REGULATION; NITRIC-OXIDE; ULCERATIVE-COLITIS; LAXATIVE ACTION; KAPPA-B; EXPRESSION;

D O I：

10.3390/ijms17071172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon, ultimately controlling the water transport. Recently, it was clarified that several laxatives exhibit a laxative effect by changing the AQP3 expression level in the colon. In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon. These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon. This review will focus on the physiological and pathological roles of AQP3 in the colon, and discuss clinical applications of colon AQP3.

引用

页数：10

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