(±)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis

被引：62

作者：

Luo, Qi ^{[1
,3
]}

Tian, Lei ^{[1
,2
]}

Di, Lei ^{[1
]}

Yan, Yong-Ming ^{[1
,3
]}

Wei, Xiao-Yi ^{[4
]}

Wang, Xin-Fang ^{[1
]}

Cheng, Yong-Xian ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Henan Coll Tradit Chinese Med, Zhengzhou 450008, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 06期

基金：

中国国家自然科学基金;

关键词：

POLYCYCLIC MEROTERPENOIDS; COCHLEAR; HYDROQUINONE; EXPRESSION; LUCIDUM; POTENT;

D O I：

10.1021/acs.orglett.5b00448

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(+)- and (-)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures of these substances and absolute configurations at their stereocenters were assigned using spectroscopic and computational methods along with X-ray crystallographic analysis. A plausible pathway for the biosynthesis of 1 is proposed. (-)-1 was found to be a Smad3 phosphorylation inhibitor in TGF-beta 1 induced human renal proximal tubular cells.

引用

页码：1565 / 1568

页数：4

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