Effect of osteoprotegerin gene polymorphisms on the risk of cervical spondylotic myelopathy in a Chinese population

被引:2
作者
Yu, Hai-Ming [1 ]
Chen, Xiao-Lei [2 ]
Wei, Wu [3 ]
Yao, Xue-Dong [1 ]
Sun, Jing-Qun [4 ]
Su, Xiao-Tao [5 ]
Lin, Shu-Feng [1 ]
机构
[1] Fujian Med Univ, Affiliated Hosp 2, Dept Orthopaed, 34 Zhongshan North Rd, Quanzhou 362000, Fujian, Peoples R China
[2] Second Peoples Hosp Henan Prov, Dept Orthoped, Zhengzhou 451191, Henan, Peoples R China
[3] Wuzhou Red Cross Hosp Guangxi, Dept Orthoped 1, Wuzhou 543002, Peoples R China
[4] Third Hosp Xiamen, Dept Orthopaed, Xiamen 361100, Peoples R China
[5] Univ South China, Affiliated NanHua Hosp, Hengyang 421002, Peoples R China
关键词
Osteoprotegerin; Polymorphism; Cervical spondylotic myelopathy; 950T/C; 163A/G; 1181G/C; Independent risk factor; BONE-MINERAL DENSITY; SPINAL-CORD; RANK-LIGAND; OPG; ASSOCIATION; SUSCEPTIBILITY;
D O I
10.1016/j.clineuro.2018.09.013
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction. Our study aims to explore the correlation of osteoprotegerin (OPG) gene polymorphisms and the risk factors and severity of CSM. Patients and methods: The peripheral blood samples from 494 CSM patients and 515 healthy individuals were collected for detecting the 950T/C, 1181G/C and 163A/G genotypes and genetic equilibrium of OPG in the CSM and control groups and analyzing the genotype distribution and allele frequency. The severity of CSM and the impaired segments were evaluated by the Japanese Orthopedic Association (JOA) scoring combined with cervical magnetic resonance imaging (MRI), in order to investigate the relations between the three genotypes of OPG promoter gene loci (950T/C, 163A/G and 1181G/C) and occurrence as well as severity of CSM. Results: The risk rate of TC genotype carrier suffered from CSM was 0.46, of TT genotype carrier was 0.27. The risk rate of T allele carrier suffered from CSM was 0.37. In 950T/C single nucleotide polymorphism (SNP), patients with TC, TT and T genotypes had lower risk to suffer from CSM. Conclusion: Taken together, OPG 950T/C SNP protects against CSM, and it is correlated with the severity of CSM, providing a new idea for the prevention and treatment of CSM.
引用
收藏
页码:149 / 154
页数:6
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