Haemozoin formation

被引：149

作者：

Egan, Timothy J. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2008年 / 157卷 / 02期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

haemozoin; beta-haematin; malaria; schistosoma mansoni; screening; lipid bodies;

D O I：

10.1016/j.molbiopara.2007.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Formation of malaria pigment or haemozoin is the major route of haem detoxification in the malaria parasite Plasmodium falciparum as well as several other species of haematophagous organisms, including other Plasmodium species, helminth worms such as Schistosoma mansoni and blood-sucking insects such as Rhodnius prolixus. Recent advances in our understanding of the formation of haemozoin, both from new observations that it is formed within lipid bodies in P. falciparum and S. mansoni and biomimetic studies on the formation of its synthetic counterpart beta-haematin are reviewed. The review also covers methods available for screening compounds for their ability to inhibit P-haematin formation. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：127 / 136

页数：10

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