Advances in Research on microRNAs Related to the Invasion and Metastasis of Nasopharyngeal Carcinoma

被引：3
作者：
Zhang, ShanShan [1 ]
Wang, BaiQi [1 ,2 ]
Zheng, LuLu [1 ]
Fu, ZhuQiong [1 ]
Fu, YiTing [1 ]
Huang, WeiGuo [1 ]
Cheng, AiLan [1 ]
机构：
[1] Univ South China, Hengyang Sch Med, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang 421001, Hunan, Peoples R China
[2] Univ South China, Affiliated Hosp 2, Dept Oncol Hematol, Hengyang 421001, Hunan, Peoples R China
来源：
CURRENT MOLECULAR PHARMACOLOGY | 2022年 / 15卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Nasopharyngeal carcinoma; miRNAs; EBV-encoded miRNAs; invasion; metastasis; NPC; EPSTEIN-BARR-VIRUS; EPITHELIAL-MESENCHYMAL TRANSITION; SUPPRESSES CELL-PROLIFERATION; PROMOTES METASTASIS; SIGNALING PATHWAY; TUMOR-GROWTH; MIGRATION; TARGETS; BIOMARKERS; RADIOSENSITIVITY;
D O I：
10.2174/1874467214666210614150720
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nasopharyngeal Carcinoma (NPC), which is associated with latent Epstein-Barr virus infection in most cases, is a unique epithelial malignancy arising from the nasopharyngeal mucosal lining. Accumulating evidence is providing insights into the genetic and molecular aberrations that likely drive nasopharyngeal tumor development and progression. We review recent analyses of microRNAs (miRNAs), including Epstein-Barr virus-encoded miRNAs (EBV-encoded miRNAs) and dysregulated cellular miRNAs, that may be related to the metastasis of nasopharyngeal carcinoma. The studies summarized herein have greatly expanded our knowledge of the molecular biology of NPC involving miRNAs, and they may provide new biological targets for clinical diagnosis and reveal the potential of microRNA therapeutics. However, much remains to be uncovered.
引用
收藏
页码：463 / 474
页数：12
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