Induction of Constitutive Androstane Receptor during the Development of Oxidative Stress

被引：5

作者：

Shchul'kin, A., V ^{[1
]}

Abalenikhina, Yu, V ^{[1
]}

Seidkulieva, A. A. ^{[1
]}

Ryabkov, A. N. ^{[1
]}

Yakusheva, E. N. ^{[1
]}

机构：

[1] Ryazan State Med Univ, Minist Hlth Russian Federat, Ryazan, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 171卷 / 05期

关键词：

constitutive androstane receptor; oxidative stress; hydrogen peroxide; Caco-2 cell line; HYDROGEN-PEROXIDE; NUCLEAR RECEPTOR; ACTIVATION;

D O I：

10.1007/s10517-021-05280-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of 3-, 24-, and 72-h exposure to H2O2 in concentrations of 0.1-100.0 mu M on the level of constitutive androstane receptor in Caco-2 cells. It was shown that 3- and 24-h incubation with H2O2 in all concentrations had no effect on the level of constitutive androstane receptors. Increasing the incubation time to 72 h led to an increase in the level of constitutive androstane receptor at H2O2 concentrations of 5, 10, and 50 mu M and to a decrease at a concentration of 100 mu M. Antioxidant glutathione (1 mM) in parallel to the prooxidant neutralized these changes.

引用

页码：615 / 618

页数：4

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