Associations between gene polymorphisms of the apelin-APJ system and the risk of hypertension

被引:8
作者
Huang, Feng [1 ]
Zhu, Pengli [1 ]
Huang, Qiuxia [1 ]
Yuan, Yin [1 ]
Lin, Fan [1 ]
Li, Qiaowei [1 ]
机构
[1] Fujian Med Univ, Fujian Inst Clin Geriatr, Fujian Prov Hosp, Dept Geriatr Med, Fuzhou 350001, Peoples R China
关键词
Apelin-APJ system; primary hypertension; single nucleotide polymorphism; BLOOD-PRESSURE RESPONSES; RECEPTOR; EXPRESSION; EPISTASIS; VARIANTS; LIGAND;
D O I
10.3109/08037051.2016.1156905
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The aim of this study was to assess the associations between single nucleotide polymorphisms (SNPs) of the apelin and APJ (apelin receptor) genes and the risk of hypertension in people living in the south-east coastal area of China. A cross-sectional study involving 1031 participants was performed. Genotypes of the apelin (rs3115757, rs56204867 and rs3761581) and APJ (rs7119375 and rs9943582) genes were determined by the TaqMan (R) MGB probe method. For male patients, the frequencies of mutant alleles in the three apelin gene SNPs were significantly different between the hypertension and control groups (all p<0.05), while no significant difference was obtained for frequencies of mutant alleles in the two APJ gene SNPs (p>0.05). For females, the frequencies of mutant alleles in all five SNPs were not significantly different between the hypertension and control groups (all p>0.05). After adjusting for several factors, the risk of developing hypertension increased significantly in patients, regardless of gender, carrying rs3115757-C, rs56204867-C or rs3761581-A allele (all p<0.05). The optimal gene-gene interaction model for both males and females with regard to hypertension was apelin rs3761581-apelin rs3115757-APJ rs7119375. In conclusion, gene polymorphisms of the apelin-APJ system are associated with susceptibility to hypertension.
引用
收藏
页码:257 / 262
页数:6
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