Hydroxylamine as a Source for Nitric Oxide in Metal-Free 2,2,6,6-Tetramethylpiperidine N-Oxyl Radical (TEMPO) Catalyzed Aerobic Oxidation of Alcohols

被引：42

作者：

Wertz, Sebastian ^{[1
]}

Studer, Armido ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 01期

关键词：

aerobic oxidation; alcohols; catalysis; hydroxylamine; nitric oxide; 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO); SELECTIVE OXIDATION; MOLECULAR-OXYGEN; CHEMOSELECTIVE OXIDATION; NITROXYL RADICALS; BENZYLIC ALCOHOLS; MILD CONDITIONS; ALDEHYDES; EFFICIENT; KETONES; SALTS;

D O I：

10.1002/adsc.201000703

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The communication reports on the metal-free 2,2,6,6-tetramethylpiperidine N-oxyl radical (TEMPO) catalyzed aerobic oxidation of various alcohols to aldehydes and ketones. A novel catalyst system that uses 1-4 mol% of TEMPO in combination with 4-6 mol% of aqueous hydroxylamine is introduced. No other additives are necessary and corrosive by-products are not formed during oxidation. Nitric oxide which is important for the catalytic cycle is generated in situ by reaction of the hydroxylamine with TEMPO. A catalytic cycle for the overall oxidation process is suggested.

引用

页码：69 / 72

页数：4

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