Increased Cerebellar-Default-Mode-Network Connectivity in Drug-Naive Major Depressive Disorder at Rest

被引:61
作者
Guo, Wenbin [1 ]
Liu, Feng [2 ]
Liu, Jianrong [1 ]
Yu, Miaoyu [1 ]
Zhang, Zhikun [1 ]
Liu, Guiying [1 ]
Xiao, Changqing [1 ]
Zhao, Jingping [3 ]
机构
[1] Guangxi Med Univ, Affiliated Hosp 1, Mental Hlth Ctr, Nanning 530021, Guangxi, Peoples R China
[2] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Sichuan, Peoples R China
[3] Cent S Univ, Key Lab Psychiat & Mental Hlth Hunan Prov, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
FUNCTIONAL CONNECTIVITY; CINGULATE CORTEX; STATE; BRAIN; 1ST-EPISODE; ABNORMALITIES; METAANALYSIS; MOOD; MRI; CIRCUIT;
D O I
10.1097/MD.0000000000000560
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The default-mode network (DMN) has been implicated in the neurobiology of major depressive disorder (MDD), and the cerebellum is suggested to be involved in high-order cognitive network such as the DMN. However, the specific contribution of the cerebellum to the DMN alterations remains equivocal. This study was conducted to examine the cerebellar-DMN connectivity in drug-naive MDD directly by using the cerebellum Crus I as seeds. Forty-four drug-naive MDD patients and 44 healthy controls participated in the resting-state scan. Functional connectivity (FC) was applied to analyze the images. Significantly increased FCs were observed between the right Crus I and the right inferior frontal cortex (orbital part)/superior temporal pole, bilateral MPFC (orbital part), and left middle temporal gyrus in the patients compared with the controls. There was a significantly positive correlation between the z values of the right Crus I-bilateral MPFC (orbital part) connectivity and the scores of Automatic Thoughts Questionnaire in the patients (r = 0.329, P = 0.029). The findings reveal that depressed patients have increased cerebellar-DMN connectivity with clinical significance, and thus highlight the contribution of the cerebellum to the DMN alterations in neurobiology of MDD.
引用
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页数:7
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