Amyloid deposits and inflammatory infiltrates in sporadic inclusion body myositis: the inflammatory egg comes before the degenerative chicken

被引:92
作者
Benveniste, Olivier [1 ,2 ,3 ]
Stenzel, Werner [4 ]
Hilton-Jones, David [5 ]
Sandri, Marco [6 ]
Boyer, Olivier [7 ,8 ]
van Engelen, Baziel G. M. [9 ]
机构
[1] Univ Paris 06, INSERM, GH Pitie Salpetriere, AP HP,Dept Med Interne,U974,DHU 12B, Paris, France
[2] Univ Paris 06, INSERM, GH Pitie Salpetriere, AP HP,Immunol Clin,U974,DHU 12B, Paris, France
[3] Ctr Reference Pathol Neuromusculaires Paris Est, Inst Myol, Paris, France
[4] Charite, Dept Neuropathol, D-13353 Berlin, Germany
[5] John Radcliffe Hosp, Dept Neurol, Oxford OX3 9DU, England
[6] Univ Padua, Dept Biomed Sci, Venetian Inst Mol Med, Padua, Italy
[7] INSERM, U905, Rouen, France
[8] Univ Rouen, IRIB, Rouen, France
[9] Radboud Univ Nijmegen, Med Ctr, Dept Neurol, NL-6525 ED Nijmegen, Netherlands
关键词
Inclusion body myositis; Pathogenesis; Immune responses; Autoimmunity; Amyloid deposits; MHC CLASS-I; CYTOSOLIC 5'-NUCLEOTIDASE 1A; REGULATORY T-CELLS; SKELETAL-MUSCLE; PROTEIN-DEGRADATION; AUTOIMMUNE MYOSITIS; UP-REGULATION; DOUBLE-BLIND; GNE GENE; S-IBM;
D O I
10.1007/s00401-015-1384-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Sporadic inclusion body myositis (sIBM) is the most frequently acquired myopathy in patients over 50 years of age. It is imperative that neurologists and rheumatologists recognize this disorder which may, through clinical and pathological similarities, mimic other myopathies, especially polymyositis. Whereas polymyositis responds to immunosuppressant drug therapy, sIBM responds poorly, if at all. Controversy reigns as to whether sIBM is primarily an inflammatory or a degenerative myopathy, the distinction being vitally important in terms of directing research for effective specific therapies. We review here the pros and the cons for the respective hypotheses. A possible scenario, which our experience leads us to favour, is that sIBM may start with inflammation within muscle. The rush of leukocytes attracted by chemokines and cytokines may induce fibre injury and HLA-I overexpression. If the protein degradation systems are overloaded (possibly due to genetic predisposition, particular HLA-I subtypes or ageing), amyloid and other protein deposits may appear within muscle fibres, reinforcing the myopathic process in a vicious circle.
引用
收藏
页码:611 / 624
页数:14
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