A microbial TRP-like polycystic-kidney-disease-related ion channel gene

被引:43
作者
Palmer, CP [1 ]
Aydar, E [1 ]
Djamgoz, MBA [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England
关键词
ion channel; PKD2; polycystic kidney disease; polycystin; Schizosaccharomyces pombe; transient receptor potential;
D O I
10.1042/BJ20041710
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ion channel genes have been discovered in many microbial organisms. We have investigated a microbial TRP (transient receptor potential) ion channel gene which has most similarity to polycystic-kidney-disease-related ion channel genes. We have shown that this gene (pkd2) is essential for cellular viability, and is involved in cell growth and cell wall synthesis. Expression of this gene increases following damage to the cell wall. This fission yeast pkd2 gene, orthologues of which are found in all eukaryotic cells, appears to be a key signalling component in the regulation of cell shape and cell wall synthesis in yeast through an interaction with a Rho1-GTPase. A model for the mode of action of this Schizosaccharomyces pombe protein in a Ca2+ signalling pathway is hypothesized.
引用
收藏
页码:211 / 219
页数:9
相关论文
共 49 条
  • [21] Mechanosensitive ion channels: molecules of mechanotransduction
    Martinac, B
    [J]. JOURNAL OF CELL SCIENCE, 2004, 117 (12) : 2449 - 2460
  • [22] Ion channel surprises: Prokaryotes do it again!
    Miller, C
    [J]. NEURON, 2000, 25 (01) : 7 - 9
  • [23] PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
    Mochizuki, T
    Wu, GQ
    Hayashi, T
    Xenophontos, SL
    Veldhuisen, B
    Saris, JJ
    Reynolds, DM
    Cai, YQ
    Gabow, PA
    Pierides, A
    Kimberling, WJ
    Breuning, MH
    Deltas, CC
    Peters, DJM
    Somlo, S
    [J]. SCIENCE, 1996, 272 (5266) : 1339 - 1342
  • [24] MORENO S, 1991, METHOD ENZYMOL, V194, P795
  • [25] NADASDY T, 1995, J AM SOC NEPHROL, V5, P1462
  • [26] The small GTP-binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe
    Nakano, K
    Arai, R
    Mabuchi, I
    [J]. GENES TO CELLS, 1997, 2 (11) : 679 - 694
  • [27] Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
    Nauli, SM
    Alenghat, FJ
    Luo, Y
    Williams, E
    Vassilev, P
    Lil, XG
    Elia, AEH
    Lu, WN
    Brown, EM
    Quinn, SJ
    Ingber, DE
    Zhou, J
    [J]. NATURE GENETICS, 2003, 33 (02) : 129 - 137
  • [28] Construction of vectors and a genomic library for use with his3-deficient strains of Schizosaccharomyces pombe
    Ohi, R
    Feoktistova, A
    Gould, KL
    [J]. GENE, 1996, 174 (02) : 315 - 318
  • [29] A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca2+-permeable channel in the yeast vacuolar membrane
    Palmer, CP
    Zhou, XL
    Lin, JY
    Loukin, SH
    Kung, C
    Saimi, Y
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) : 7801 - 7805
  • [30] Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase
    Qadota, H
    Python, CP
    Inoue, SB
    Arisawa, M
    Anraku, Y
    Zheng, Y
    Watanabe, T
    Levin, DE
    Ohya, Y
    [J]. SCIENCE, 1996, 272 (5259) : 279 - 281