A microbial TRP-like polycystic-kidney-disease-related ion channel gene

被引：44

作者：

Palmer, CP ^{[1
]}

Aydar, E ^{[1
]}

Djamgoz, MBA ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England

来源：

BIOCHEMICAL JOURNAL | 2005年 / 387卷

关键词：

ion channel; PKD2; polycystic kidney disease; polycystin; Schizosaccharomyces pombe; transient receptor potential;

D O I：

10.1042/BJ20041710

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ion channel genes have been discovered in many microbial organisms. We have investigated a microbial TRP (transient receptor potential) ion channel gene which has most similarity to polycystic-kidney-disease-related ion channel genes. We have shown that this gene (pkd2) is essential for cellular viability, and is involved in cell growth and cell wall synthesis. Expression of this gene increases following damage to the cell wall. This fission yeast pkd2 gene, orthologues of which are found in all eukaryotic cells, appears to be a key signalling component in the regulation of cell shape and cell wall synthesis in yeast through an interaction with a Rho1-GTPase. A model for the mode of action of this Schizosaccharomyces pombe protein in a Ca2+ signalling pathway is hypothesized.

引用

页码：211 / 219

页数：9

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