Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis

被引：86

作者：

Khasigov, PZ ^{[1
]}

Podobed, OV ^{[1
]}

Gracheva, TS ^{[1
]}

Salbiev, KD ^{[1
]}

Grachev, SV ^{[1
]}

Berezov, TT ^{[1
]}

机构：

[1] Sechenov Moscow Med Acad, Moscow 119992, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2003年 / 68卷 / 07期

关键词：

matrix metalloproteinases; membrane-bound metalloproteinases; tissue inhibitors of metalloproteinases; invasion and metastasis of tumor cells;

D O I：

10.1023/A:1025051214001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of various matrix metalloproteinases (MMP)-such as gelatinases, stromelysins, matrilysin, collagenase-3, and membrane-bound MMP (MB-MMP)-in tumor invasion and metastasis is discussed. Data suggesting significance for malignant growth of the expression level of these enzymes and also of their activators and inhibitors are presented. It is concluded that at different stages of tumor progression the activity of different MMPs is displayed, which is regulated by various growth factors and oncogenes. Different malignancies are characterized by changes in activities of specific MMPs. Data are presented which show significance of the ratio between the MMP activity and that of tissue inhibitors of metalloproteinases (TIMP) in tumor invasion and metastasis, especially in connection with a dual role of TIMP as both MMP inhibitors and activators.

引用

页码：711 / 717

页数：7

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