Potential application development of Sr/HCOOH metal organic framework in osteoarthritis

被引：19

作者：

Li, Zhen ^{[1
,2
,3
]}

Li, Zhenjian ^{[1
]}

Li, Sijing ^{[6
]}

Wang, Kui ^{[1
]}

Ma, Fenbo ^{[1
]}

Tang, Bin ^{[1
,4
,5
]}

机构：

[1] Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China

[2] Wuhan Univ, Dept Phys, Sch Phys & Technol, Wuhan 430072, Peoples R China

[3] Wuhan Univ, Sch Phys & Technol, Minist Educ, Key Lab Artificial Micro & Nanostruct, Wuhan 430072, Peoples R China

[4] Guangdong Prov Key Lab Cell Microenvironm & Dis R, Shenzhen, Guangdong, Peoples R China

[5] Shenzhen Key Lab Cell Microenvironm, Shenzhen 518055, Peoples R China

[6] Southern Med Univ, Dept Orthoped, Zhujiang Hosp, Guangzhou, Guangdong, Peoples R China

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2020年 / 294卷

关键词：

Metal organic framework; Strontium; Anti-inflammation; Biocompatibility; STRONTIUM RANELATE; CARTILAGE; RESORPTION;

D O I：

10.1016/j.micromeso.2019.109835

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Metal Organic Frameworks (MOFs) are widely used in various engineering applications, including energy storage, chemical catalysis, etc. However, their potential functions in disease therapy, especially alkaline-earth based MOFs, still need to be developed. In this study, Sr/HCOOH-MOF is successfully prepared and characterized by using XRD, FTIR, TGA, SEM and BET. Drug loading and releasing experiments proved that only 3% ketoprofen was loaded on the Sr/HCOOH-MOF and approximately 80% ketoprofen was released from it after 8 h. Moreover, the potential application of Sr/HCOOH-MOF on attenuating osteoarthritis is evaluated in vitro. Sr/HCOOH-MOF is biocompatible within given doses. Furthermore, it can significantly inhibit the gene expression of IL-1 beta, iNOS and RANKL. Therefore, Sr/HCOOH-MOF could be a promising compound for attenuating osteoarthritis more than a drug delivery system.

引用

页数：5