Homeopathic ligand-free palladium as a catalyst in the Heck reaction. A comparison with a palladacycle

被引：531
作者：
de Vries, AHM [1 ]
Mulders, JMCA [1 ]
Mommers, JHM [1 ]
Henderickx, HJW [1 ]
de Vries, JG [1 ]
机构：
[1] DSM Pharma Chem Adv Synth, Catalysis & Dev, NL-6160 MD Geleen, Netherlands
来源：
ORGANIC LETTERS | 2003年 / 5卷 / 18期
关键词：
D O I：
10.1021/ol035184b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Ligand-free Pd(OAc)(2) can be used as a catalyst in the Heck reaction of aryl bromides as long as the amount of catalyst is kept between 0.01 and 0.1 mol %. At higher concentrations palladium black forms and the reaction stops. The actual catalyst is monomeric. Palladacycles merely serve as a source of ligand-free palladium in Heck reactions of aryl bromides.
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收藏
页码：3285 / 3288
页数：4
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