Extracapsular extension and tumor implants in lymph nodes with canine mammary carcinoma metastasis: Study of the impact on survival

被引：5

作者：

Goncalves, A. D. B. B. ^{[1
]}

de Pinho, T. C. Reis ^{[1
]}

Toledo, F. A. O. ^{[2
]}

Balabram, D. ^{[3
]}

Ferreira, E. ^{[1
]}

Campos, M. R. A. ^{[1
]}

Cassali, G. D. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Patol Geral, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Clin & Cirurgia Vet, Escola Vet, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, Ave Prof Alfredo Balena 190, BR-30130100 Belo Horizonte, MG, Brazil

来源：

RESEARCH IN VETERINARY SCIENCE | 2021年 / 139卷

关键词：

Mammary carcinoma; Dogs; Lymph node metastasis; Extracapsular extension; Tumor implant; BREAST-CANCER PATIENTS; PROGNOSTIC VALUE; SPREAD; PARAMETERS; EXPRESSION;

D O I：

10.1016/j.rvsc.2021.07.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Regional lymph node status impacts survival in dogs with malignant mammary tumors. However, few studies have evaluated extracapsular extension and tumor implants in regional lymph node metastases in dogs with mammary carcinoma. Therefore, 84 cases of mammary carcinomas with metastases in inguinal and/or axillary lymph nodes from female dogs of different breeds and a total of 139 metastatic lymph nodes were evaluated by routine histological staining. Clinical and pathological characteristics of primary tumors as well as the presence of extracapsular extension and tumor implants in the lymph nodes were analyzed, in addition to survival. One to 5 lymph nodes were evaluated in each case. Extracapsular extension and tumor implants were present in 17.9% and 39.3% of cases, respectively. The simultaneous presence of extracapsular extension and tumor implants were associated with an increased risk of death (hazard ratio 10.46). In addition, "special type carcinomas", high histological grade (grade III), and presence of extracapsular extension associated with tumor implants were related to a worse prognosis and shorter survival times (p < 0.05). Based on these results, we highlight the importance of identifying extracapsular extension and tumor implants in dogs with metastatic mammary car-cinomas, as they are associated with a higher risk of death and shorter survival.

引用

页码：87 / 93

页数：7

共 35 条

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