Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscle

被引：17

作者：

Kuwabara, Satoshi

Misawa, Sonoko

Takahashi, Hirokatsu

Sawai, Setsu

Kanai, Kazuaki

Nakata, Miho

Mori, Masahiro

Hattori, Takamichi

Yuki, Nobuhiro

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, Chiba, Japan

[2] Dokkyo Med Univ, Res Inst Neuroimmunol Dis, Dept Neurol, Tochigi, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 189卷 / 1-2期

关键词：

anti-GQ1b antibody; Miller Fisher syndrome; neuromuscular transmission; single fiber electromyography; motor nerve terminal;

D O I：

10.1016/j.jneuroim.2007.07.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-ganglioside GQ1b antibody induces neuromuscular blocking on mouse phrenic nerve-diaphragm preparations. Several reports suggest that patients with this antibody show abnormal neuromuscular transmission in the facial or limb muscles, but limb muscle weakness is unusual in Miller Fisher syndrome that is often associated with anti-GQ1b antibody. To determine whether anti-GQ1b sera affect neuromuscular transmission in human limb muscles, axonal-stimulating single fiber electromyography was performed in the forearm muscle of seven patients with anti-GQ1b antibody. All showed normal jitter and no blocking. Anti-GQ1b antibody does not affect neuromuscular transmission in human limb muscles. The different findings in mouse and human may be explained by the extent of expression of GQ1b on the motor nerve terminals in the muscle examined. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：158 / 162

页数：5

共 35 条

[1] Neuromuscular blockade by IgG antibodies from patients with Guillain-Barre syndrome: A macro-patch-clamp study
Buchwald, B
Toyka, KV
Zielasek, J
Weishaupt, A
Schweiger, S
Dudel, J
[J]. ANNALS OF NEUROLOGY, 1998, 44 (06) : 913 - 922
[2] Pre-and postsynaptic blockade of neuromuscular transmission by Miller-Fisher syndrome IgG at mouse motor nerve terminals
Buchwald, B
Weishaupt, A
Toyka, KV
Dudel, J
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (01) : 281 - 290
[3] Differential blocking effects of the monoclonal anti-GQ1b IgM antibody and alpha-latrotoxin in the absence of complement at the mouse neuromuscular junction
Buchwald, B
Ahangari, R
Toyka, KV
[J]. NEUROSCIENCE LETTERS, 2002, 334 (01) : 25 - 28
[4] Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome
Buchwald, B
Bufler, J
Carpo, M
Heidenreich, F
Pitz, R
Dudel, J
Nobile-Orazio, E
Toyka, KV
[J]. NEUROLOGY, 2001, 56 (01) : 67 - 74
[5] Immunoglobulin G from a patient with Miller-Fisher syndrome rapidly and reversibly depresses evoked quantal release at the neuromuscular junction of mice
Buchwald, B
Weishaupt, A
Toyka, KV
Dudel, J
[J]. NEUROSCIENCE LETTERS, 1995, 201 (02) : 163 - 166
[6] Concanavalin A inhibits pathophysiological effects of anti-ganglioside GQ1b antibodies at the mouse neuromuscular synapse
Bullens, RWM
Halstead, SK
O'Hanlon, GM
Veitch, J
Molenaar, PC
Willison, HJ
Plomp, JJ
[J]. MUSCLE & NERVE, 2005, 31 (06) : 751 - 760
[7] SERUM ANTI-GQ(1B) IGG ANTIBODY IS ASSOCIATED WITH OPHTHALMOPLEGIA IN MILLER FISHER SYNDROME AND GUILLAIN-BARRE-SYNDROME - CLINICAL AND IMMUNOHISTOCHEMICAL STUDIES
CHIBA, A
KUSUNOKI, S
OBATA, H
MACHINAMI, R
KANAZAWA, I
[J]. NEUROLOGY, 1993, 43 (10) : 1911 - 1917
[8] SERUM IGG ANTIBODY TO GANGLIOSIDE GQ1B IS A POSSIBLE MARKER OF MILLER FISHER SYNDROME
CHIBA, A
KUSUNOKI, S
SHIMIZU, T
KANAZAWA, I
[J]. ANNALS OF NEUROLOGY, 1992, 31 (06) : 677 - 679
[9] Anti-disialosyl antibodies mediate selective neuronal or Schwann cell injury at mouse neuromuscular junctions
Halstead, SK
Morrison, I
O'Hanlon, GM
Humphreys, PD
Goodfellow, JA
Plomp, JJ
Willison, HJ
[J]. GLIA, 2005, 52 (03) : 177 - 189
[10] Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding
Jacobs, BC
O'Hanlon, GM
Bullens, RWM
Veitch, J
Plomp, JJ
Willison, HJ
[J]. BRAIN, 2003, 126 : 2220 - 2234

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