DNA alkylation properties of yatakemycin

被引：78

作者：

Parrish, JP

Kastrinsky, DB

Wolkenberg, SE

Igarashi, Y

Boger, DL

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Toyama Perfectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 36期

关键词：

D O I：

10.1021/ja035984h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Yatakemycin represents the newest and now most potent member of a class of naturally occurring antitumor compounds that includes CC-1065 and the duocarmycins, which derive their biological properties from a characteristic DNA alkylation reaction. Herein, the first description of the yatakemycin DNA alkylation properties is detailed, constituting the first such study of a naturally occurring "sandwiched" member of this class. Thus, the event, sequence selectivity, relative rate and efficiency, and reversibility of the DNA alkylation reaction of yatakemycin are described.

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页码：10971 / 10976

页数：6

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