The DUX4 protein is a co-repressor of the progesterone and glucocorticoid nuclear receptors

被引：6

作者：

Quintero, Julieta ^{[1
]}

Saad, Nizar Y. ^{[2
,3
]}

Pagnoni, Sabrina M. ^{[1
]}

Jacquelin, Daniela K. ^{[1
]}

Gatica, Laura, V ^{[1
]}

Harper, Scott Q. ^{[2
,3
]}

Rosa, Alberto L. ^{[1
,4
]}

机构：

[1] Univ Catolica Cordoba, Fac Ciencias Quim, Lab Genet & Biol Mol, IRNASUS,CONICET, Av Armada Argentina 3555,X5016DHK, Cordoba, Argentina

[2] Nationwide Childrens Hosp, Ctr Gene Therapy, Res Inst, Columbus, OH USA

[3] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA

[4] Fdn Allende, CONICET, Cordoba, Argentina

来源：

FEBS LETTERS | 2022年 / 596卷 / 20期

关键词：

co-regulator; DUX4; facioscapulohumeral muscular dystrophy; glucocorticoids; hormone nuclear receptor; progesterone; FACIOSCAPULOHUMERAL MUSCULAR-DYSTROPHY; TRANSCRIPTION FACTORS; GENES; FSHD; SEQUENCE; LOCUS; CELLS; ACETYLATION; COACTIVATOR; ACTIVATION;

D O I：

10.1002/1873-3468.14416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DUX4 is a transcription factor required during early embryonic development in placental mammals. In this work, we provide evidence that DUX4 is a co-repressor of nuclear receptors (NRs) of progesterone (PR) and glucocorticoids (GR). The DUX4 C-ter and N-ter regions, including the nuclear localization signals and homeodomain motifs, contribute to the co-repressor activity of DUX4 on PR and GR. Immunoprecipitation studies, using total protein extracts of cells expressing tagged versions of DUX4 and GR, support that these proteins are physically associated. Our studies suggest that DUX4 could modulate gene expression by co-regulating the activity of hormone NRs. This is the first report highlighting a potential endocrine role for DUX4.

引用

页码：2644 / 2658

页数：15

共 70 条

[1]

Abdel-Hafiz Hany A, 2018, Diseases, V6, DOI 10.3390/diseases6010005

[2] Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation [J].

Ansseau, Eugenie ;

Eidahl, Jocelyn O. ;

Lancelot, Celine ;

Tassin, Alexandra ;

Matteotti, Christel ;

Yip, Cassandre ;

Liu, Jian ;

Leroy, Baptiste ;

Hubeau, Celine ;

Gerbaux, Cecile ;

Cloet, Samuel ;

Wauters, Armelle ;

Zorbo, Sabrina ;

Meyer, Pierre ;

Pirson, Isabelle ;

Laoudj-Chenivesse, Dalila ;

Wattiez, Ruddy ;

Harper, Scott Q. ;

Belayew, Alexandra ;

Coppee, Frederique .

PLOS ONE, 2016, 11 (01)

[3] Aberrant Splicing in Transgenes Containing Introns, Exons, and V5 Epitopes: Lessons from Developing an FSHD Mouse Model Expressing a D4Z4 Repeat with Flanking Genomic Sequences [J].

Ansseau, Eugenie ;

Domire, Jacqueline S. ;

Wallace, Lindsay M. ;

Eidahl, Jocelyn O. ;

Guckes, Susan M. ;

Giesige, Carlee R. ;

Pyne, Nettie K. ;

Belayew, Alexandra ;

Harper, Scott Q. .

PLOS ONE, 2015, 10 (03)

[4] DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast Proliferation [J].

Ansseau, Eugenie ;

Laoudj-Chenivesse, Dalila ;

Marcowycz, Aline ;

Tassin, Alexandra ;

Vanderplanck, Celine ;

Sauvage, Sebastien ;

Barro, Marietta ;

Mahieu, Isabelle ;

Leroy, Axelle ;

Leclercq, India ;

Mainfroid, Veronique ;

Figlewicz, Denise ;

Mouly, Vincent ;

Butler-Browne, Gillian ;

Belayew, Alexandra ;

Coppee, Frederique .

PLOS ONE, 2009, 4 (10)

[5]

ARAHATA K, 1995, MUSCLE NERVE, pS56

[6] Role of co-regulators in metabolic and transcriptional actions of thyroid hormone [J].

Astapova, Inna .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2016, 56 (03) :R73-R97

[7] DUX4 expressing immortalized FSHD lymphoblastoid cells express genes elevated in FSHD muscle biopsies, correlating with the early stages of inflammation [J].

Banerji, Christopher R. S. ;

Panamarova, Maryna ;

Zammit, Peter S. .

HUMAN MOLECULAR GENETICS, 2020, 29 (14) :2285-2299

[8] Facioscapulohumeral muscular dystrophy 1 patients participating in the UK FSHD registry can be subdivided into 4 patterns of self-reported symptoms [J].

Banerji, Christopher R. S. ;

Cammish, Phillip ;

Evangelista, Teresinha ;

Zammit, Peter S. ;

Straub, Volker ;

Marini-Bettolo, Chiara .

NEUROMUSCULAR DISORDERS, 2020, 30 (04) :315-328

[9] Active genes in junk DNA?: Characterization of DUX genes embedded within 3.3 kb repeated elements [J].

Beckers, MC ;

Gabriëls, J ;

van der Maarel, S ;

De Vriese, A ;

Frants, RR ;

Collen, D ;

Belayew, A .

GENE, 2001, 264 (01) :51-57

[10] Progesterone reduces the migration of mast cells toward the chemokine stromal cell-derived factor-1/CXCL12 with an accompanying decrease in CXCR4 receptors [J].

Belot, Marie-Pierre ;

Abdennebi-Najar, Latifa ;

Gaudin, Francoise ;

Lieberherr, Michele ;

Godot, Veronique ;

Taieb, Joelle ;

Emilie, Dominique ;

Machelon, Veronique .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 292 (05) :E1410-E1417

← 1 2 3 4 5 6 7 →