Copper Catalyzed Direct Synthesis of Nitriles from Acyl Azides

被引：5

作者：

Chen, Yang ^{[1
]}

Liu, Yu ^{[1
]}

Zhang, Xiao ^{[1
]}

Lu, Da ^{[1
]}

Yang, Lixin ^{[1
]}

Deng, Junfeng ^{[1
]}

Deng, Shengqi ^{[1
]}

机构：

[1] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610052, Sichuan, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 43期

关键词：

acyl azide; reduction; silane; copper-catalyzed; PRIMARY AMIDES; IN-SITU; DEHYDRATION; COMPLEXES; REDUCTION; MILD; NHC;

D O I：

10.1002/slct.201802918

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and general protocol for the copper catalyzed reductive elimination of acyl azides to nitriles using triethoxysilane is reported. Various nitriles are obtained in moderate to excellent yields with good functional group tolerance and high chemoselectivity under mild conditions. This new reaction can be performed using a cheap copper catalyst, a simple NHC ligand, an inexpensive silane, and with low catalyst loading.

引用

页码：12325 / 12329

页数：5

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